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. 2024 Dec 31;20(1):2323861.
doi: 10.1080/21645515.2024.2323861. Epub 2024 Mar 18.

Mapping the intellectual structure and landscape of colorectal cancer immunotherapy: A bibliometric analysis

Qin Ling Ou  1   2 , Yong Long Chang  1 , Jin Hui Liu  2 , Hai Xia Yan  1 , Lin Zi Chen  1 , Duan Yang Guo  2 , Si Fang Zhang  1
Affiliations

Mapping the intellectual structure and landscape of colorectal cancer immunotherapy: A bibliometric analysis

Qin Ling Ou et al. Hum Vaccin Immunother. .

Abstract

Immunotherapy, particularly immune checkpoint inhibitor (ICIs) therapy, stands as an innovative therapeutic approach currently garnering substantial attention in cancer treatment. It has become a focal point of numerous studies, showcasing significant potential in treating malignancies, including lung cancer and melanoma. The objective of this research is to analyze publications regarding immunotherapy for colorectal cancer (CRC), investigating their attributes and identifying the current areas of interest and cutting-edge advancements. We took into account the publications from 2002 to 2022 included in the Web of Science Core Collection. Bibliometric analysis and visualization were conducted using CiteSpace, VOSviewer, R-bibliometrix, and Microsoft Excel. The quantity of publications associated with this domain has been steadily rising over the years, encompassing 3753 articles and 1498 reviews originating from 573 countries and regions, involving 19,166 institutions, 1011 journals, and 32,301 authors. In this field, China, the United States, and Italy are the main countries that come forward for publishing. The journal with the greatest impact factor is CA-A Cancer Journal for Clinicians. Romain Cohen leads in the number of publications, while Le Dt stands out as the most influential author. The immune microenvironment and immune infiltration are emerging as key hotspots and future research directions in this domain. This research carries out an extensive bibliometric examination of immunotherapy for colorectal cancer, aiding researchers in understanding current focal points, investigating possible avenues for research, and recognizing forthcoming development trends.

Keywords: CiteSpace; Colorectal cancer; VOSviewer; bibliometric study; immunotherapy; research trends.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
Flow chart for search strategy of publications.
Figure 2.
Figure 2.
The annual growth trends of publication during the period 2002–2022.
Figure 3.
Figure 3.
(a) Country/region number of publications. (b) Worldwide visualization map of publication collaborations. (c) Cooperation network among top 20 countries/regions based on quantity of publications. (d) Visualization of institutions with publications concerning colorectal cancer immunotherapy.
Figure 4.
Figure 4.
Visualization analysis of author collaborations (a) and author co-citations (b) generated by VOSviewer. Co-occurrence network diagram of journals (c) and co-cited network diagram of journals (d) generated by VOSviewer.
Figure 5.
Figure 5.
The co-citation network of literature (a) and labels clustering of co-cited literature based on LLR algorithm (b) generated by CiteSpace.
Figure 6.
Figure 6.
Co-occurrence network graph (a) and clustering timeline graph (b) of keyword generated by CiteSpace. (c) Top 25 most cited keywords.
Figure 7.
Figure 7.
(a) Top 10 published journals ranked by H-index. (b) Top 10 authors ranked by H-index. The research trend quadrant chart (c) and research theme trend map (d) based on keyword.
See this image and copyright information in PMC

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