Interleukin-12: Structure, Function, and Its Impact in Colorectal Cancer
- PMID: 38498032
- DOI: 10.1089/jir.2023.0190
Interleukin-12: Structure, Function, and Its Impact in Colorectal Cancer
Abstract
Interleukin 12 (IL-12) is a heterodimer consisting of 2 subunits, p35 and p40, with unique associations and interacting functions with its family members. IL-12 is one of the most important cytokines regulating the immune system response and is integral to adaptive immunity. IL-12 has shown marked therapeutic potential in a variety of tumor types. This review therefore summarizes the characteristics of IL-12 and its application in tumor treatment, focusing on its antitumor effects in colorectal cancer (CRC) and potential radiosensitization mechanisms. We aim to provide a current reference for IL-12 and other potential CRC treatment strategies.
Keywords: IL-12; antitumor therapy; colorectal cancer; immunotherapy.
Similar articles
-
Production of biologically active equine interleukin 12 through expression of p35, p40 and single chain IL-12 in mammalian and baculovirus expression systems.Equine Vet J. 2001 Nov;33(7):693-8. doi: 10.2746/042516401776249426. Equine Vet J. 2001. PMID: 11770992
-
The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases.Med Microbiol Immunol. 2004 Feb;193(1):1-17. doi: 10.1007/s00430-003-0186-x. Epub 2003 Jun 27. Med Microbiol Immunol. 2004. PMID: 12836019 Review.
-
Expression and Function of IL12/23 Related Cytokine Subunits (p35, p40, and p19) in Giant-Cell Arteritis Lesions: Contribution of p40 to Th1- and Th17-Mediated Inflammatory Pathways.Front Immunol. 2018 Apr 20;9:809. doi: 10.3389/fimmu.2018.00809. eCollection 2018. Front Immunol. 2018. PMID: 29731755 Free PMC article.
-
Oncolytic adenovirus expressing IL-23 and p35 elicits IFN-γ- and TNF-α-co-producing T cell-mediated antitumor immunity.PLoS One. 2013 Jul 3;8(7):e67512. doi: 10.1371/journal.pone.0067512. Print 2013. PLoS One. 2013. PMID: 23844018 Free PMC article.
-
Novel IL-12 family members shed light on the orchestration of Th1 responses.Trends Immunol. 2003 Apr;24(4):207-12. doi: 10.1016/s1471-4906(03)00067-x. Trends Immunol. 2003. PMID: 12697453 Free PMC article. Review.
Cited by
-
The Immune Environment in Colorectal Adenoma: A Systematic Review.Biomedicines. 2025 Mar 12;13(3):699. doi: 10.3390/biomedicines13030699. Biomedicines. 2025. PMID: 40149674 Free PMC article. Review.
-
Non-clinical evaluation of pmIL12 gene therapy for approval of the phase I clinical study.Sci Rep. 2024 Sep 27;14(1):22288. doi: 10.1038/s41598-024-73314-x. Sci Rep. 2024. PMID: 39333733 Free PMC article.
-
In-depth plasma N-glycoproteome profiling using narrow-window data-independent acquisition on the Orbitrap Astral mass spectrometer.Nat Commun. 2025 Mar 13;16(1):2497. doi: 10.1038/s41467-025-57916-1. Nat Commun. 2025. PMID: 40082474 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
