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. 2024 Jun;148(3):145-153.
doi: 10.1007/s10633-024-09969-8. Epub 2024 Mar 18.

Morphological and Functional Correlations in Acute Central Serous Chorioretinopathy

Peter Kiraly  1   2   3 , Maja Šuštar Habjan  4 , Jaka Smrekar  5 , Polona Jaki Mekjavić  6   7   8
Affiliations

Morphological and Functional Correlations in Acute Central Serous Chorioretinopathy

Peter Kiraly et al. Doc Ophthalmol. 2024 Jun.

Abstract

Purpose: We evaluate morphological and functional correlations in patients with acute central serous chorioretinopathy (CSC).

Methods: A prospective study was conducted on 50 patients with an acute CSC episode lasting less than 3 months. At baseline, assessments included optical coherence tomography (OCT), best-corrected visual acuity (BCVA), contrast sensitivity (CS), microperimetry (MP), and multifocal electroretinography (mfERG). A correlation analysis between OCT morphological parameters (maximal subretinal fluid height (SRF), central retinal thickness (CRT), and macular volume (MV)) and functional parameters was conducted on the affected eye for each patient.

Results: Among the morphological parameters, SRF showed the strongest correlations with functional parameters (r absolute value range = 0.10-0.70). Weak correlations were observed between BCVA and morphological parameters (r absolute value range = 0.14-0.26). Average retinal sensitivity (MP-A) was the functional parameter displaying the most robust negative correlation with morphological parameters (r absolute value range = 0.61-0.70). In contrast, average contrast sensitivity (CS-A) and mfERG average amplitude density in the first (mfERG-A1) and second (mfERG-A2) ring showed weak to moderate (r absolute value range = 0.35-0.56) yet statistically significantly nonzero correlations.

Conclusions: SRF and CRT could serve as the most representative morphological proxies for visual function deficit in acute CSC patients. Retinal sensitivity, as measured by MP, may be superior to BCVA in clinical research studies or when an in-depth visual function evaluation is needed.

Keywords: CSC; CSR; Central serous chorioretinopathy; Correlations; Functional correlations; Morphological correlations.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Correlation analysis between best-corrected visual acuity (BCVA) and central retinal thickness (CRT) (A); BCVA an maximal height of subretinal fluid (SRF) (B); average retinal sensitivity (MP-A) and CRT (C); MP-A and maximal height of SRF (D)
Fig. 2
Fig. 2
Acute central serous chorioretinopathy (CSC) patient with excellent best-corrected visual acuity (BCVA) (A) and severely reduced retinal sensitivity on microperimetry (B) and reduced amplitude densities on multifocal electroretinogram (C). Central retinal thickness (CRT); macular volume (MV); and subretinal fluid (SRF)
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References

    1. Daruich A, Matet A, Dirani A, Bousquet E, Zhao M, Farman N, et al. Central serous chorioretinopathy: recent findings and new physiopathology hypothesis. Prog Retin Eye Res. 2015;48:82–118. doi: 10.1016/j.preteyeres.2015.05.003. - DOI - PubMed
    1. Wang M, Munch IC, Hasler PW, Prünte C, Larsen M. Central serous chorioretinopathy. Acta Ophthalmol. 2008;86(2):126–145. doi: 10.1111/j.1600-0420.2007.00889.x. - DOI - PubMed
    1. Spaide RF, Gemmy Cheung CM, Matsumoto H, Kishi S, Boon CJF, van Dijk EHC, et al. Venous overload choroidopathy: a hypothetical framework for central serous chorioretinopathy and allied disorders. Prog Retin Eye Res. 2022;86:100973. doi: 10.1016/j.preteyeres.2021.100973. - DOI - PubMed
    1. Gerendas BS, Kroisamer JS, Buehl W, Rezar-Dreindl SM, Eibenberger KM, Pablik E, et al. Correlation between morphological characteristics in spectral-domain-optical coherence tomography, different functional tests and a patient's subjective handicap in acute central serous chorioretinopathy. Acta Ophthalmol. 2018;96(7):e776–e782. doi: 10.1111/aos.13665. - DOI - PubMed
    1. Kiraly P, Smrekar J, Mekjavić PJ. Visual function during and after an acute central serous chorioretinopathy episode. Doc Ophthalmol. 2022;145(1):27–35. doi: 10.1007/s10633-022-09875-x. - DOI - PubMed

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