Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Apr;50(4):587-589.
doi: 10.1007/s00134-024-07374-y. Epub 2024 Mar 18.

Knowing the ropes of vasopressor dosing: a focus on norepinephrine

Affiliations

Knowing the ropes of vasopressor dosing: a focus on norepinephrine

Eduardo Kattan et al. Intensive Care Med. 2024 Apr.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Cardiovascular effects of norepinephrine. *Anrep effect: autoregulatory mechanism consisting of an increase in myocardial contractility and stroke volume due to sustained afterload-induced myocardial stretching. CPP coronary perfusion pressure, MSFP mean systemic filling pressure, P pressure, V volume, CO cardiac output, MAP mean arterial pressure

References

    1. Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021;47(11):1181–1247. doi: 10.1007/s00134-021-06506-y. - DOI - PMC - PubMed
    1. Scheeren TWL, Bakker J, De Backer D, et al. Current use of vasopressors in septic shock. Ann Intensive Care. 2019;9(1):20. doi: 10.1186/s13613-019-0498-7. - DOI - PMC - PubMed
    1. Westfall TC, Macarthur H, Westfall DP. Adrenergic agonists and antagonists. In: Brunton LL, Hilal-Dandan R, Knollmann BC, editors. Goodman & Gilman’s: the pharmacological basis of therapeutics. New York, NY: McGraw-Hill Education; 2023.
    1. Beloeil H, Mazoit JX, Benhamou D, Duranteau J. Norepinephrine kinetics and dynamics in septic shock and trauma patients. Br J Anaesth. 2005;95:782–788. doi: 10.1093/bja/aei259. - DOI - PubMed
    1. Bakker J, Kattan E, Annane D, et al. Current practice and evolving concepts in septic shock resuscitation. Intensive Care Med. 2022;48:148–163. doi: 10.1007/s00134-021-06595-9. - DOI - PubMed

LinkOut - more resources