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. 2024 Mar 18;14(1):48.
doi: 10.1038/s41408-024-01035-5.

Genetically determined telomere length and risk for haematologic diseases: results from large prospective cohorts and Mendelian Randomization analysis

Yang Li #  1   2 , Jia Chen #  1   2 , Ting Sun #  1   2 , Yunfei Chen  1   2 , Rongfeng Fu  1   2 , Xiaofan Liu  1   2 , Feng Xue  1   2 , Wei Liu  1   2 , Mankai Ju  1   2 , Xinyue Dai  1   2 , Huan Dong  1   2 , Huiyuan Li  1   2 , Wentian Wang  1   2 , Ying Chi  1   2 , Lei Zhang  3   4   5
Affiliations

Genetically determined telomere length and risk for haematologic diseases: results from large prospective cohorts and Mendelian Randomization analysis

Yang Li et al. Blood Cancer J. .

Abstract

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Study design and Mendelian randomization results.
A Study design (a) The causal diagram illustrating the standard Mendelian randomization (MR) analysis with instrumental variables (IV) and the three necessary assumptions. (b) An illustrative diagram demonstrating the IV assumptions utilized in the multivariable MR model. B Two-sample single-variable Mendelian randomization results of telomere length on risk of multiple haematologic diseases in the discovery cohort. C Multivariable Mendelian randomization results of telomere length and five epigenetic age acceleration on risk of multiple haematologic diseases in the discovery cohort. MR, Mendelian randomization; IV, instrumental variable; DNAm PAI-1, DNA methylation-estimated plasminogen activator inhibitor-1; nSNP, number of single nucleotide polymorphism; OR, odds ratio; 95% CI, The 95% confidence intervals.
See this image and copyright information in PMC

References

    1. Ahmad H, Jahn N, Jaiswal S. Clonal Hematopoiesis and Its Impact on Human Health. Annu Rev Med. 2023;74:249–60. doi: 10.1146/annurev-med-042921-112347. - DOI - PubMed
    1. Nogueira BMD, Machado CB, Montenegro RC, DE Moraes MEA, Moreira-Nunes CA. Telomere Length and Hematological Disorders: A Review. Vivo. 2020;34:3093–101. doi: 10.21873/invivo.12142. - DOI - PMC - PubMed
    1. Horvath S, Raj K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat Rev Genet. 2018;19:371–84. doi: 10.1038/s41576-018-0004-3. - DOI - PubMed
    1. Fransquet PD, Wrigglesworth J, Woods RL, Ernst ME, Ryan J. The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis. Clin Epigenet. 2019;11:62. doi: 10.1186/s13148-019-0656-7. - DOI - PMC - PubMed
    1. Codd V, Wang Q, Allara E, Musicha C, Kaptoge S, Stoma S, et al. Polygenic basis and biomedical consequences of telomere length variation. Nat Genet. 2021;53:1425–33. doi: 10.1038/s41588-021-00944-6. - DOI - PMC - PubMed

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