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Meta-Analysis
. 2024 Mar 18;14(1):6494.
doi: 10.1038/s41598-024-55730-1.

Estimate the burden of malnutrition among children with cerebral palsy in Sub-Saharan Africa: a systematic review with meta-analysis

Ermias Sisay Chanie  1 , Natnael Moges  2 , Fikadie Dagnew Baye  3 , Gebrehiwot Berie Mekonnen  3 , Mengistu Melak Fekadie  3 , Lakachew Yismaw Bazezew  2 , Denekew Tenaw Anley  4 , Melkamu Aderajew Zemene  4 , Natnael Atnafu Gebeyehu  5 , Getachew Asmare Adella  6 , Gizachew Ambaw Kassie  7 , Misganaw Asmamaw Mengstie  8 , Mohammed Abdu Seid  9 , Endeshaw Chekol Abebe  10 , Molalegn Mesele Gesese  5 , Kirubel Dagnaw Tegegne  11 , Yenealem Solomon Kebede  12 , Berihun Bantie  13 , Sefineh Fenta Feleke  14 , Tadesse Asmamaw Dejenie  15 , Wubet Alebachew Bayih  16 , Amare Kassaw  3 , Anteneh Mengist Dessie  4 , Melkalem Mamuye Azanaw  4 , Sewunt Sisay Chanie  17
Affiliations
Meta-Analysis

Estimate the burden of malnutrition among children with cerebral palsy in Sub-Saharan Africa: a systematic review with meta-analysis

Ermias Sisay Chanie et al. Sci Rep. .

Abstract

Malnutrition is more prevalent among children with cerebral palsy and a major factor for child morbidity and mortality in children with different co-morbidity, especially in Sub-Saharan Africa: The main aim of this systematic review and meta-analysis was to estimate the burden of malnutrition among children with cerebral palsy in Sub-Saharan Africa. We searched PubMed, Web of Science, Google Scholar, Research Gate, and institutional repositories for papers that reported the proportion of malnutrition among children with cerebral palsy that were published between December 2010 and September 2023. Data were retrieved using the standardized JBI data extraction checklist through Microsoft Excel, and then exported to STATA 17 for further analysis. DerSimonian and Laird's estimator was used to calculate the pooled effect size in the random-effects model. Statistics such as the Cochran Q test and I2 test were employed to measure heterogeneity. Egger's test and the funnel plot were used to look for publication bias. This systematic review and meta-analysis used 16 studies from Sub-Saharan Africa to estimate the proportion of malnutrition among 2,120 children with cerebral palsy. The pooled proportion of malnutrition among children with cerebral palsy in Sub-Saharan Africa by using random-effects model analysis was found to be 59.7% (95% CI; 49.8-69.6). The proportion of malnutrition was also estimated by sample sizes categorized as ≤ 120 and > 120, and the proportion of malnutrition was found to be 54.0 (95% CI: 44.7-63.3) and 64.5 (95% CI: 50.5-78.5). Moreover, the proportion of malnutrition was estimated by accounting for the difference in the year of publication. In this regard, the study classified before ≤ 2017 and > 2017, and the proportion of malnutrition was found to be 53.7 (95% CI: 38.0-69.3) and 62.5 (95% CI: 49.7-75.3) in Sub-Saharan Africa respectively. Malnutrition among children with cerebral in Sub-Saharan Africa was found to be very high. Hence, enhancing and developing strategic guidelines for malnutrition screening, prevention, and nutritional support are crucial among children with cerebral palsy. Furthermore, systematic review, randomized control trials, and qualitative studies are recommended to understand the burden more among children with cerebral palsy in the continent.

Keywords: Children with cerebral palsy; Malnutrition; Sub-Saharan Africa.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
The PRISMA flow diagram of searching process.
Figure 2
Figure 2
Forest plot to test of malnutrition estimation among children with cerebral palsy in Sub-Saharan Africa.
Figure 3
Figure 3
The proportion of malnutrition estimation among children with cerebral palsy by sample sizes categories.
Figure 4
Figure 4
The proportion of malnutrition estimation among children with cerebral palsy by year of publications categories.
Figure 5
Figure 5
Funnel plot tests for the proportion of malnutrition among children with cerebral palsy in Sub-Saharan Africa.
Figure 6
Figure 6
The sensitivity test for the proportion of malnutrition among children with cerebral palsy in Sub-Saharan Africa.
See this image and copyright information in PMC

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