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. 1979 Apr 15;180(1):233-6.
doi: 10.1042/bj1800233.

Defective calcium handling and insulin release in islets from diabetic Chinese hamsters

E G Siegel, C B Wollheim, G W Sharp, L Herberg, A E Renold

Defective calcium handling and insulin release in islets from diabetic Chinese hamsters

E G Siegel et al. Biochem J. .

Abstract

In pancreatic islets from normal Chinese hamsters preloaded with 45Ca2+, glucose-induced biphasic insulin release was associated with increased 45Ca2+ efflux; islets from diabetic hamsters showed decreased insulin release and no increase in 45Ca2+ efflux. The lack of stimulated 45Ca2+ efflux persisted even when glucose-induced insulin release was potentiated by 3-isobutyl-1-methylxanthine. Since glucose-stimulated 45Ca2+ uptake by diabetic islets was not impaired, a defect in intracellular Ca2+ handling may be involved in the defective insulin release of the diabetic Chinese hamster.

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