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. 2024 Mar 4:15:1361466.
doi: 10.3389/fendo.2024.1361466. eCollection 2024.

Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea

MengShi Tao  1   2 , Xiaoqi Dong  1 , Jinjing Tu  1 , Qing Fang  1 , Chuan Shao  1   2
Affiliations

Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea

MengShi Tao et al. Front Endocrinol (Lausanne). .

Abstract

Background: Obstructive sleep apnea (OSA) is an important but frequently overlooked risk factor for hypertension (HTN). The prevalence of hypertension is high in patients with OSA, but the differences in clinical symptoms and comorbidities between patients with OSA with hypertension and those with normal blood pressure have not been fully defined.

Methods: This study retrospectively analyzed OSA patients diagnosed for the first time in Lihuili Hospital Affiliated to Ningbo University from 2016 to 2020. Patients were divided into an OSA group with hypertension and an OSA group without hypertension. The sociodemographic information, clinical symptoms, comorbidities, and polysomnography results of the two groups were compared. The independent risk factors associated with hypertension in patients with OSA were explored.

Results: A total of 1108 patients with OSA initially diagnosed were included in the study, including 387 with hypertension and 721 without. Compared with OSA patients without hypertension, OSA patients with hypertension were older; had a higher body mass index (BMI) and Epworth sleepiness score (ESS); a higher incidence of nocturia; and a higher proportion of diabetes mellitus, coronary heart disease, and cerebrovascular disease. Multivariate analysis showed age (odds ratio [OR]:1.06, 95% confidence interval [CI]:1.04-1.08), BMI (OR:1.17, 95% CI:1.11-1.23), ESS score (OR:0.97, 95%CI: 0.94-1.00) and nocturia symptoms (OR:1.64, 95% CI:1.19-2.27) was independently associated with hypertension in OSA patients, and comorbid diabetes (OR: 3.86, 95% CI: 2.31-6.45), coronary heart disease (OR: 1.90, 95% CI:1.15-3.16), and ischemic stroke (OR: 3.69,95% CI:1.31-10.40) was independently associated with hypertension in OSA patients.

Conclusion: Compared to OSA patients with normal blood pressure, OSA patients with hypertension had more significant daytime sleepiness, more frequent nocturnal urination, and a higher risk of diabetes, coronary heart disease, and cerebrovascular disease.

Keywords: comorbidity; daytime sleepiness; hypertension; nocturia; obstructive sleep apnea.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of the patients’ inclusion process. PSG, polysomnography; OSA, obstructive sleep apnea; PAP, positive airway pressure.
See this image and copyright information in PMC

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References

    1. Zhao B, Cao Z, Xie Y, Shi Y, Zhang Y, Liu S, et al. . The relationship of tongue fat content and efficacy of uvulopalatopharyngoplasty in Chinese patients with obstructive sleep apnea. BMC Surg. (2023) 23:254. doi: 10.1186/s12893-023-02144-x - DOI - PMC - PubMed
    1. Gonzaga C, Bertolami A, Bertolami M, Amodeo C, Calhoun D. Obstructive sleep apnea, hypertension and cardiovascular diseases. J Hum hypertension. (2015) 29:705–12. doi: 10.1038/jhh.2015.15 - DOI - PubMed
    1. Chen L, Bai C, Zheng Y, Wei L, Han C, Yuan N, et al. . The association between sleep architecture, quality of life, and hypertension in patients with obstructive sleep apnea. Sleep breathing = Schlaf Atmung. (2023) 27:191–203. doi: 10.1007/s11325-022-02589-z - DOI - PubMed
    1. Sircu V, Colesnic SI, Covantsev S, Corlateanu O, Sukhotko A, Popovici C, et al. . The burden of comorbidities in obstructive sleep apnea and the pathophysiologic mechanisms and effects of CPAP. Clocks sleep. (2023) 5:333–49. doi: 10.3390/clockssleep5020025 - DOI - PMC - PubMed
    1. Hirani R, Smiley A. A scoping review of sleep apnea: Where do we stand? Life (Basel Switzerland). (2023) 13:387. doi: 10.3390/life13020387 - DOI - PMC - PubMed

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