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. 2024 Mar 19;21(1):9.
doi: 10.1007/s10433-024-00804-2.

The causal relationship between sleep disturbances and the risk of frailty: a two-sample Mendelian randomization study

Zong-Xiao Lu #  1 , Ni Sang #  1 , Rong-Chao Liu  1 , Bo-Han Li  1 , Meng-Yao Zhang  1 , Ming-Hui Zhang  1 , Meng-Cheng Cheng  1 , Guo-Cui Wu  2
Affiliations

The causal relationship between sleep disturbances and the risk of frailty: a two-sample Mendelian randomization study

Zong-Xiao Lu et al. Eur J Ageing. .

Abstract

Objective: Adequate sleep is closely related to people's health. However, with increasing age, the quality of sleep worsens. At the same time, among elderly individuals, frailty is also a disturbing factor, which makes elderly individuals more vulnerable to negative factors. To explore the relationship between the two, we conducted this study.

Methods: In this paper, independent genetic variations related to insomnia, sleep duration and daytime sleepiness were selected as IVs, and related genetic tools were used to search published genome-wide association studies for a two-sample Mendelian randomization (TSMR) analysis. The inverse-variance weighted (IVW) method was used as the main Mendelian randomization analysis method. Cochran's Q test was used to test heterogeneity, MR‒Egger was used to test horizontal pleiotropy, and the MR-PRESSO test was used to remove outliers.

Results: According to our research, insomnia (OR = 1.10, 95% CI 1.03-1.17, P = 2.59e-97), long sleep duration (OR = 0.66, 95% CI 0.37-1.17, P = 0.02), short sleep duration (OR = 1.30, 95% CI 1.22-1.38, P = 2.23e-17) and daytime sleepiness (OR = 1.49, 95% CI 1.25-1.77, P = 0.96e-4) had a bidirectional causal relationship with frailty.

Conclusions: Our research showed that there is a causal relationship between sleep disturbances and frailty. This result was obtained by a TSMR analysis, which involves the use of genetic variation as an IV to determine causal relationships between exposure and outcome. Future TSMR studies should include a larger sample for analysis.

Keywords: Causal relationship; Frailty; Mendelian randomization study; Sleep disturbances.

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Conflict of interest statement

The authors declare no conflicts of interest.

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