Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar 19;14(1):6579.
doi: 10.1038/s41598-024-57377-4.

Association between previous surgical termination of pregnancy and pregnancy outcomes in frozen-thawed embryo transfer cycles of IVF/ICSI: a retrospective cohort study

Shuai Zhang  1 , Hanhan Tang  2 , Minglian Zhou  3
Affiliations

Association between previous surgical termination of pregnancy and pregnancy outcomes in frozen-thawed embryo transfer cycles of IVF/ICSI: a retrospective cohort study

Shuai Zhang et al. Sci Rep. .

Abstract

This study aimed to evaluate the effect of previous surgical termination of pregnancy (STP) on pregnancy outcomes in women undergoing FET cycles of IVF/ICSI. Retrospective cohort study. Reproductive Center of Maternal and Child Health Care Hospital in Lianyungang city. Data were selected from all IVF/ICSI FET cycles performed between January 2014 and December 2020. A total of 761 cycles met the criteria were included in this study. The primary outcome measures were clinical pregnancy and live birth rates. Secondary outcome measures were biochemical pregnancy rate, spontaneous abortion rate, and preterm birth rate. After adjustments for a series of potential confounding factors, the previous STP was an influential factor in reducing FET cycle clinical pregnancy rate compared with women who had not previously undergone STP (OR = 0.614, 95% CI 0.413-0.911, P = 0.016). The effect of the previous STP on the live birth rate was not statistically significant. (OR = 0.745, 95% CI 0.495-1.122, P = 0.159). Also, an increase in the number of previous STPs relative to only 1-time abortion was an independent risk factor in reducing clinical pregnancy rate and live birth rate (OR = 0.399,95% CI 0.162-0.982, p = 0.046; OR = 0.32,95% CI 0.119-0.857, p = 0.023). Previous STP was an independent factor contributing to the decline in FET cycle clinical pregnancy rates.

Keywords: Endometrium; Freeze–thaw embryo transfer; Induced abortion; Induced termination of pregnancy; Infertility.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flow chart of the study.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. ESHRE Capri Workshop Group. ITP. Hum. Reprod.32(6), 1160–1169 (2017). 10.1093/humrep/dex071 (Erratum in: Hum Reprod. 2018 Apr 1;33(4):768).
    1. Bearak J, Popinchalk A, Ganatra B, Moller AB, Tunçalp Ö, Beavin C, Kwok L, Alkema L. Unintended pregnancy and abortion by income, region, and the legal status of abortion: Estimates from a comprehensive model for 1990–2019. Lancet Glob. Health. 2020;8(9):e1152–e1161. doi: 10.1016/S2214-109X(20)30315-6. - DOI - PubMed
    1. National Health Commission of the People’s Republic of China. China health statistics yearbook . in Chinese. Peking Union Medical College Press; 2021. p. 2021.
    1. Grimes DA, Creinin MD. ITP: An overview for internists. Ann Intern Med. 2004;140(8):620–626. doi: 10.7326/0003-4819-140-8-200404200-00009. - DOI - PubMed
    1. Zhou W, Olsen J. Are complications after an ITP associated with reproductive failures in a subsequent pregnancy? Acta Obstet. Gynecol. Scand. 2003;82(2):177–181. doi: 10.1034/j.1600-0412.2003.00005.x. - DOI - PubMed