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Editorial
. 2024 Mar 20;5(1):10.
doi: 10.1186/s43556-024-00171-5.

Manipulating mitochondrial electron flow: a novel approach to enhance tumor immunogenicity

Junyu Wang  1 , Anren Zhang  2 , Min Wu  3   4 , Shugang Qin  5
Affiliations
Editorial

Manipulating mitochondrial electron flow: a novel approach to enhance tumor immunogenicity

Junyu Wang et al. Mol Biomed. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Fig. 1
Fig. 1
Schematic illustration of CII-mediated tumor immunogenicity. It outlines two methods: Mcj-KO and CII activity inhibition, both increasing succinate and changing the epigenetics of MHC-APP genes. This includes suppressing KDM4 and KDM5, raising NLRC5 levels, and boosting MHC-APP gene transcription. Using 3-Nitropropionic Acid enhances MHC-APP gene expression and antigen presentation in tumors, leading to higher IFN-γ and GZMB production by T cells, targeting tumors effectively
See this image and copyright information in PMC

Comment on

  • Manipulating mitochondrial electron flow enhances tumor immunogenicity.
    Mangalhara KC, Varanasi SK, Johnson MA, Burns MJ, Rojas GR, Esparza Moltó PB, Sainz AG, Tadepalle N, Abbott KL, Mendiratta G, Chen D, Farsakoglu Y, Kunchok T, Hoffmann FA, Parisi B, Rincon M, Vander Heiden MG, Bosenberg M, Hargreaves DC, Kaech SM, Shadel GS. Mangalhara KC, et al. Science. 2023 Sep 22;381(6664):1316-1323. doi: 10.1126/science.abq1053. Epub 2023 Sep 21. Science. 2023. PMID: 37733872 Free PMC article.

References

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