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Review
. 2024 Mar 19;24(1):167.
doi: 10.1186/s12872-024-03814-1.

Paclitaxel-induced acute myocardial infarction: a case report and literature review

Gi Eun Kim  1 , Ayman R Ibrahim  2 , Duha Shalatouni  2 , Nadin H Abouzeid  2 , Fahmi Othman  3
Affiliations
Review

Paclitaxel-induced acute myocardial infarction: a case report and literature review

Gi Eun Kim et al. BMC Cardiovasc Disord. .

Abstract

Background: Paclitaxel is a chemotherapeutic agent commonly used for ovarian, lung, breast carcinoma, and Kaposi's sarcoma. Its common side effects include hypersensitivity reaction, bone marrow suppression, and peripheral neuropathy. However, a rare and life-threatening side effect is paclitaxel-induced myocardial infarction.

Case presentation: A 71-year-old man with type 2 diabetes mellitus, hypertension, heavy smoking history, previous coronary artery disease with percutaneous coronary intervention (PCI) in left anterior descending artery (LAD), and non-small lung cancer presented with non-ST elevation myocardial infarction during infusion of paclitaxel infusion. Coronary angiogram showed de novo three vessel disease with 70% stenosis in ostial to distal left main artery (LM) and 80% in-stent re-stenosis in proximal to mid left anterior descending artery.

Conclusions: Physicians should be keeping this in mind when dealing with patients on paclitaxel, especially if they have previous risk factors for coronary artery disease.

Keywords: Acute myocardial infarction; Case report; Chemotherapy; Paclitaxel.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Initial electrocardiogram
See this image and copyright information in PMC

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