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. 2024 Mar 19;25(1):220.
doi: 10.1186/s12891-024-07345-w.

Lifestyle factors and subacromial impingement syndrome of the shoulder: potential associations in finnish participants

Zhengtao Lv #  1 , Jiarui Cui #  2 , Jiaming Zhang #  2 , Li He  3
Affiliations

Lifestyle factors and subacromial impingement syndrome of the shoulder: potential associations in finnish participants

Zhengtao Lv et al. BMC Musculoskelet Disord. .

Abstract

Background: Emerging evidence has indicated the associations between subacromial impingement syndrome (SIS) of shoulder and lifestyle factors. However, whether unhealthy lifestyle factors causally increase SIS risk is not determined. This study aims to evaluate whether lifestyle factors are the risk factors of SIS.

Methods: A two-sample Mendelian randomization (MR) study was designed to evaluate the effect of 11 lifestyle factors on SIS risk. Causality was determined using the inverse-variance weighted method to calculate the odds ratio (OR) and establish a 95% confidence interval (CI). Weighted median method, MR-Egger method and MR-PRESSO method were conducted as sensitivity analysis.

Results: Four lifestyle factors were identified causally associated with an increased risk of SIS using the IVW method: insomnia (OR: 1.66 95% CI 1.38, 2.00; P = 8.86 × 10- 8), short sleep duration (OR: 1.53 95% CI 1.14, 2.05: P = 0.0043), mobile phone usage (OR: 4.65, 95% CI 1.59, 13.64; P = 0.0051), and heavy manual or physical work (OR: 4.24, 95% CI 2.17, 8.26; P = 2.20 × 10- 5). Another causal but weak association was found between smoking initiation on SIS (OR: 1.17, 95% CI 1.01, 1.35; P = 3.50 × 10- 2). Alcohol, coffee consumption, physical activity, sedentary behavior, sleep duration and computer usage were not found to be causally associated with an increased risk of SIS. Sensitivity analyses indicated that the MR estimates were robust and no heterogeneity and pleiotropy were identified in these MR analyses.

Conclusion: Sleep habits and shoulder usage were identified as causal factors for SIS. This evidence supports the development of strategies aimed at improving sleep behaviors and optimizing shoulder usage patterns as effective measures to prevent SIS.

Keywords: Causal effect; Lifestyle factor; Mendelian randomization; Risk; Subacromial impingement syndrome.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Forest plot of the associations between modifiable lifestyle factors (exposure) and subacromial impingement syndrome of shoulder (outcome); The odds of subacromial impingement syndrome of shoulder was compared between different levels of lifestyle factor
See this image and copyright information in PMC

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