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Review
. 2024 Mar 19;19(1):19.
doi: 10.1186/s13722-024-00448-8.

Treatment of alcohol use disorder in patients with alcohol-associated liver disease: Innovative approaches and a call to action

Lamia Y Haque  1 , Paola Zuluaga  2 , Robert Muga  2 , Daniel Fuster  3
Affiliations
Review

Treatment of alcohol use disorder in patients with alcohol-associated liver disease: Innovative approaches and a call to action

Lamia Y Haque et al. Addict Sci Clin Pract. .

Abstract

Alcohol-associated liver disease is currently the leading cause of liver transplantation and liver deaths both in Europe and the United States. Efficacious treatments exist for alcohol use disorder, but they are seldomly prescribed for patients who need them. Besides, the presence of liver cirrhosis can complicate pharmacological treatment choices. In this review, we discuss established and innovative treatment strategies to treat unhealthy alcohol use in patients with alcohol-associated liver disease. We also describe the experience of our own institutions, Hospital Universitari Germans Trias i Pujol in Badalona (Spain) and Yale-New Haven Health and Yale Medicine (Connecticut. United States of America).

Keywords: Addiction medicine; Alcohol use disorder; Alcohol-associated liver disease; Hepatology; Treatment.

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Conflict of interest statement

None to disclose.

Figures

Fig. 1
Fig. 1
Goals for integrated and collaborative care for patients with AUD and ALD. Treating AUD and promoting abstinence is the primary goal among patients with unhealthy alcohol use of AUD to prevent evolution to end stage liver disease
See this image and copyright information in PMC

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References

    1. Simonetto DA, Shah VH, Kamath PS. Outpatient management of alcohol-related liver disease. Lancet Gastroenterol Hepatol. 2020;5(5):485–493. doi: 10.1016/S2468-1253(19)30415-7. - DOI - PMC - PubMed
    1. Grant BF, Chou SP, Saha TD, et al. Prevalence of 12-month alcohol use, high-risk drinking, and DSM-IV alcohol use disorder in the United States, 2001–2002 to 2012–2013: results from the national epidemiologic survey on alcohol and related conditions. JAMA Psychiat. 2017;74(9):911–923. doi: 10.1001/JAMAPSYCHIATRY.2017.2161. - DOI - PMC - PubMed
    1. Grucza RA, Sher KJ, Kerr WC, et al. Trends in adult alcohol use and binge drinking in the early 21st-century United States: a meta-analysis of 6 national survey series. Alcohol Clin Exp Res. 2018;42(10):1939–1950. doi: 10.1111/ACER.13859. - DOI - PMC - PubMed
    1. Tapper EB, Parikh ND. Mortality due to cirrhosis and liver cancer in the United States, 1999–2016: observational study. BMJ. 2018 doi: 10.1136/BMJ.K2817. - DOI - PMC - PubMed
    1. Kim D, Li AA, Gadiparthi C, et al. Changing trends in etiology-based annual mortality from chronic liver disease, from 2007 through 2016. Gastroenterology. 2018;155(4):1154–1163.e3. doi: 10.1053/J.GASTRO.2018.07.008. - DOI - PMC - PubMed

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