Tolerance development in cow's milk-allergic children receiving amino acid-based formula with synbiotics: 36-Months follow-up of a randomized controlled trial (PRESTO Study)
- PMID: 38504410
- DOI: 10.1002/jpn3.12104
Tolerance development in cow's milk-allergic children receiving amino acid-based formula with synbiotics: 36-Months follow-up of a randomized controlled trial (PRESTO Study)
Abstract
The objective of the present study is to assess the rates of acquired tolerance to cow's milk (CM) after 36 months in subjects who consumed amino acid-based formula with synbiotics (AAF-S) or amino acid-based formula without synbiotics (AAF) during a 1-year intervention period in early life as part of the PRESTO study (Netherlands Trial Register number NTR3725). Differences in CM tolerance development between groups were analysed using a logistic regression model. Results show that the proportion of subjects (mean [±SD] age, 3.8 ± 0.27 years) who developed CM tolerance after 36 months was similar in the group receiving AAF-S (47/60 [78%]) and in the group receiving AAF (49/66 [74%]) (p = 0.253), that is, figures comparable to natural outgrowth of CM allergy. Our data suggest that the consumption of AAF and absence of exposure to CM peptides do not slow down CM tolerance acquisition.
Keywords: cow's milk allergy; elemental formula; prebiotics; probiotics.
© 2024 The Authors. Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
References
REFERENCES
-
- Candy DCA, Van Ampting MTJ, Oude Nijhuis MM, et al. A synbiotic-containing amino-acid-based formula improves gut microbiota in non-IgE-mediated allergic infants. Pediatr Res. 2018;83:677-686. doi:10.1038/pr.2017.270
-
- Fox AT, Wopereis H, Van Ampting MTJ, et al. A specific synbiotic-containing amino acid-based formula in dietary management of cow's milk allergy: a randomized controlled trial. Clin Transl Allergy. 2019;9:5. doi:10.1186/s13601-019-0241-3
-
- Wopereis H, van Ampting MTJ, Cetinyurek-Yavuz A, et al. A specific synbiotic-containing amino acid-based formula restores gut microbiota in non-IgE mediated cow's milk allergic infants: a randomized controlled trial. Clin Transl Allergy. 2019;9:27. doi:10.1186/s13601-019-0267-6
-
- Sorensen K, Cawood AL, Gibson GR, Cooke LH, Stratton RJ. Amino acid formula containing synbiotics in infants with cow's milk protein allergy: a systematic review and meta-analysis. Nutrients. 2021;13:935. doi:10.3390/nu13030935
-
- Sorensen K, Cawood AL, Cooke LH, Acosta-Mena D, Stratton RJ. The use of an amino acid formula containing synbiotics in infants with cow's milk protein allergy-effect on clinical outcomes. Nutrients. 2021;13:2205. doi:10.3390/nu13072205
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources