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. 2024 Apr;10(2):e876.
doi: 10.1002/cre2.876.

Remineralization potential of dentifrices with calcium sodium phosphosilicate and functionalized tri-calcium phosphate in the deeper incipient carious lesions: An in vitro study

Shafiq Aziz  1 , Carolina Loch  1 , Kai Chun Li  1 , Robert Anthonappa  2 , Alison Meldrum  1 , Manikandan Ekambaram  1
Affiliations

Remineralization potential of dentifrices with calcium sodium phosphosilicate and functionalized tri-calcium phosphate in the deeper incipient carious lesions: An in vitro study

Shafiq Aziz et al. Clin Exp Dent Res. 2024 Apr.

Abstract

Objectives: This study evaluated the remineralization potential of calcium sodium phosphosilicate and functionalized tri-calcium phosphate (f-TCP) dentifrices in deeper incipient carious lesions (ICLs).

Materials and methods: Artificial ICLs were created by placing premolars into demineralizing solutions. Teeth were randomly assigned into four groups: calcium sodium phosphosilicate (Group 1), f-TCP (Group 2), 1450 ppm fluoride (Group 3), and distilled water (Group 4), which were subjected to 10-day pH cycling. Mineral density (MD) was assessed using microcomputed tomography (Micro-CT), while hardness (H) and elastic modulus (EM) were assessed using nanomechanical testing.

Results: MD % gain was higher in Groups 1-3 than in Group 4. In addition, Groups 1 and 2 exhibited significantly higher MD % gain than Group 3. Also, Groups 1-3 showed significantly higher EM and H values than Group 4 in the outer enamel area; yet, Groups 1 and 2 displayed significantly higher EM and H values than Groups 3 and 4 in the inner enamel.

Conclusions: The MD, EM, and H of ICLs significantly increased with the addition of calcium sodium phosphosilicate or f-TCP to fluoridated dentifrices compared to standard fluoride dentifrices. The added active ingredients remineralized the deeper parts of the ICLs, while remineralization at the lesion surface was similar between tested dentifrices.

Keywords: dentifrices; enamel caries; fluorides; tricalcium phosphate.

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Conflict of interest statement

The author declare no conflict of interest.

Figures

Figure 1
Figure 1
Micro‐CT images of representative specimens showing demineralized enamel (DE), treated enamel (TE), and sound enamel (SE). Remineralization of the lesion is evident in Group 1, SRP (a) and Group 2, CTC (b). Slight remineralization of the lesion is evident in Group 3, CCP (c). No remineralization and partial erosion of lesion (arrow) are seen in Group 4, DI (d).
Figure 2
Figure 2
24 h pH cycling model + solution change. *Start of the cycle.
See this image and copyright information in PMC

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