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Multicenter Study
. 2024 Mar 20;14(1):6690.
doi: 10.1038/s41598-024-55378-x.

Comparison of mortality and outcomes of four respiratory viruses in the intensive care unit: a multicenter retrospective study

Baptiste Grangier  1 , Charles-Hervé Vacheron  1   2 , Donatien De Marignan  1 , Jean-Sebastien Casalegno  3   4 , Sandrine Couray-Targe  5 , Audrey Bestion  5 , Florence Ader  6   7 , Jean-Christophe Richard  8   9 , Emilie Frobert  3   4 , Laurent Argaud  10 , Thomas Rimmele  11 , Anne-Claire Lukaszewicz  11 , Frédéric Aubrun  12 , Frédéric Dailler  13 , Jean-Luc Fellahi  14 , Julien Bohe  1 , Vincent Piriou  1   15 , Bernard Allaouchiche  1   16 , Arnaud Friggeri  1   4 , Florent Wallet  17   18 ; Lyon Sud COVID-19 ICU
Collaborators, Affiliations
Multicenter Study

Comparison of mortality and outcomes of four respiratory viruses in the intensive care unit: a multicenter retrospective study

Baptiste Grangier et al. Sci Rep. .

Abstract

This retrospective study aimed to compare the mortality and burden of respiratory syncytial virus (RSV group), SARS-CoV-2 (COVID-19 group), non-H1N1 (Seasonal influenza group) and H1N1 influenza (H1N1 group) in adult patients admitted to intensive care unit (ICU) with respiratory failure. A total of 807 patients were included. Mortality was compared between the four following groups: RSV, COVID-19, seasonal influenza, and H1N1 groups. Patients in the RSV group had significantly more comorbidities than the other patients. At admission, patients in the COVID-19 group were significantly less severe than the others according to the simplified acute physiology score-2 (SAPS-II) and sepsis-related organ failure assessment (SOFA) scores. Using competing risk regression, COVID-19 (sHR = 1.61; 95% CI 1.10; 2.36) and H1N1 (sHR = 1.87; 95% CI 1.20; 2.93) were associated with a statistically significant higher mortality while seasonal influenza was not (sHR = 0.93; 95% CI 0.65; 1.31), when compared to RSV. Despite occurring in more severe patients, RSV and seasonal influenza group appear to be associated with a more favorable outcome than COVID-19 and H1N1 groups.

Keywords: ARDS; CARV; Influenza; RSV; SARS COV 2.

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Conflict of interest statement

The authors declare no competing interests.

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