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Review
. 2024 Mar 10;10(6):e27306.
doi: 10.1016/j.heliyon.2024.e27306. eCollection 2024 Mar 30.

Urine-derived stem cells: Promising advancements and applications in regenerative medicine and beyond

Yao Sun  1 , Huiying Zhao  1 , Shuguang Yang  1 , Guangjie Wang  1 , Leijie Zhu  1 , Chang Sun  1 , Youzhong An  1
Affiliations
Review

Urine-derived stem cells: Promising advancements and applications in regenerative medicine and beyond

Yao Sun et al. Heliyon. .

Abstract

Currently, stem cells are a prominent focus of regenerative engineering research. However, due to the limitations of commonly used stem cell sources, their application in therapy is often restricted to the experimental stage and constrained by ethical considerations. In contrast, urine-derived stem cells (USCs) offer promising advantages for clinical trials and applications. The noninvasive nature of the collection process allows for repeated retrieval within a short period, making it a more feasible option. Moreover, studies have shown that USCs have a protective effect on organs, promoting vascular regeneration, inhibiting oxidative stress, and reducing inflammation in various acute and chronic organ dysfunctions. The application of USCs has also been enhanced by advancements in biomaterials technology, enabling better targeting and controlled release capabilities. This review aims to summarize the current state of research on USCs, providing insights for future applications in basic and clinical settings.

Keywords: Extracellular vesicles; Hydrogel; Induced pluripotent stem cell; Regenerative engineering; Urine-derived stem cell.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Stem cell differentiation capacity and identification of USCs.
Fig. 2
Fig. 2
USCs and USCs-EVs act in multiple organ diseases.
Fig. 3
Fig. 3
The USCs and USCs-EVs with hydrogels.
See this image and copyright information in PMC

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