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Case Reports
. 2024 Mar;15(1):125-128.
doi: 10.1007/s13193-023-01832-7. Epub 2023 Oct 13.

Primary Testicular Mucinous Adenocarcinoma-a Case Report and Review of Literature

Vijayabhaskar Ramakrishnan  1 , Kirushna Kumar  2 , Krishna Kumar Rathnam  3 , Thalabathik Kumara Vikram  1 , Niranjana Devi  1 , Arul  4
Affiliations
Case Reports

Primary Testicular Mucinous Adenocarcinoma-a Case Report and Review of Literature

Vijayabhaskar Ramakrishnan et al. Indian J Surg Oncol. 2024 Mar.

Abstract

Testicular tumors include germ cell tumors, sex cord stromal tumors, and ovarian type epithelial tumors. Testicular mucinous tumors belong to ovarian type epithelial tumors and are extremely rare with only 31 cases reported in literature so far. Among those, mucinous adenocarcinoma constitutes only 9 cases. There are no standard treatment guidelines owing to their rarity. We report a case of primary testicular mucinous adenocarcinoma managed by orchidectomy, chemotherapy, and retroperitoneal lymph node dissection. A 44-year-old gentleman presented with right testicular tumor with infiltration and ulceration of scrotal skin. Tumor markers were within normal limits. Patient underwent orchidectomy with excision of involved scrotal skin. HPE suggested mucinous adenocarcinoma of testis. Patient was then administered chemotherapy but had progression of disease and hence taken up for retroperitoneal, bilateral pelvic, and bilateral inguinal lymph node dissection with revision of spermatic cord. Patient recovered uneventfully and is on regular follow-up 6 months now since surgery. There are no standard guidelines for the management of mucinous adenocarcinoma of testis. It is essential to rule out mucinous carcinoma of gastrointestinal tract metastasizing to testis before labeling as primary mucinous adenocarcinoma of testis. Surgery remains the mainstay of treatment in metastasis confined to retroperitoneal and inguinal lymph nodes. Further studies are needed to identify optimal chemotherapy regimen for metastatic and adjuvant scenarios.

Keywords: Orchidectomy; Ovarian type epithelial tumor; RPLND; Scrotal ulceration; Signet ring cells; Testicular mucinous adenocarcinoma; Testicular tumor.

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Conflict of interest statement

Conflict of InterestThe authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Computed tomography scan showing testicular tumor with ulceration of scrotal skin
Fig. 2
Fig. 2
Histopathological examination. a Tumor cells arranged in nest. b Tumor cells showing gland formation. c Extracellular mucin. d Signet ring cell
Fig. 3
Fig. 3
Fused PET-CT scan showing uptake in interaortocaval nodal mass
See this image and copyright information in PMC

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References

    1. Moch H, et al. The 2016 WHO classification of tumours of the urinary system and male genital organs-part A: renal, penile, and testicular tumours. Eur Urol. 2016;70(1):93–105. doi: 10.1016/j.eururo.2016.02.029. - DOI - PubMed
    1. Tanriverdi O, Tarimer ML, Pak CD, Uylas S, Alkan A, Dere Y, Yazici A, Sen S, Sahin H. Management of a patient with primary mucinous testicular adenocarcinoma as a rare case with adjuvant and metastatic sequential treatments. J Oncol Pharm Pract. 2020;26(6):1520–1523. doi: 10.1177/1078155220903374. - DOI - PubMed
    1. Iuga AC, Mull J, Batra R, Miller W. Mucinous cystadenocarcinoma of the testis: a case report. Hum Pathol. 2011;42(9):1343–1347. doi: 10.1016/j.humpath.2010.11.021. - DOI - PubMed
    1. Di Franco C, Porru D, Viglio A, Paulli M, Rovereto B. Primary paratesticular mucinous “ovarian-type” adenocarcinoma: a rare case of scrotal tumor in a patient with history of bilateral cryptorchidism. World J Nephrol Urol. 2015;4(4):260–263. doi: 10.14740/wjnu235w. - DOI
    1. Lei H, Lai L, Xu H, Bai S, Shi M, Yang L (2020) Primary mucinous adenocarcinoma of the testis: a case report and review of the literature. 10.21203/rs.3.rs-67135/v1

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