A comprehensive review on the functional role of miRNA clusters in cervical cancer
- PMID: 38511231
- DOI: 10.2217/epi-2023-0244
A comprehensive review on the functional role of miRNA clusters in cervical cancer
Abstract
Cervical cancer (CC) poses a significant health threat in women globally. MicroRNA clusters (MCs), comprising multiple miRNA-encoding genes, are pivotal in gene regulation. Various factors, including circular RNA and DNA methylation, govern MC expression. Dysregulated MC expression correlates strongly with CC development via promoting the acquisition of cancer hallmarks. Certain MCs show promise for diagnosis, prognosis and therapy selection due to their distinct expression patterns in normal, premalignant and tumor tissues. This review explains the regulation and biological functions of MCs and highlights the clinical relevance of abnormal MC expression in CC.
Keywords: cervical cancer; diagnosis; miRNA cluster; prognosis; signaling pathways; therapeutic strategies.
Plain language summary
Cervical cancer is a major global health concern, mostly caused by human papillomavirus infection, resulting in a high number of new cases and fatalities annually. This review examines the role of specific genetic variables known as microRNA clusters (MCs) in the development and progression of cervical cancer. The MCs harbor many microRNAs that control genes related to tumor proliferation, infiltration and dissemination. Understanding the functioning of these MCs can aid in early diagnosis of cervical cancer and predicting its patterns of behavior. We explore the potential benefits of assessing MC expression levels in cancer staging and prognosis, and the development of diagnostic tools and treatments. Targeting these molecular targets could provide interesting opportunities for future cancer treatments.
