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. 2024 Jul 15;130(14):2515-2527.
doi: 10.1002/cncr.35286. Epub 2024 Mar 21.

Longitudinal quality of life after sublobar resection and stereotactic body radiation therapy for early-stage non-small cell lung cancer

Juan P Wisnivesky  1   2 , Jeremy Mudd  2 , Kimberly Stone  1 , Christopher G Slatore  3   4   5 , Raja Flores  6 , Scott Swanson  7 , William Blackstock Jr  8 , Cardinale B Smith  9 , Mark Chidel  10 , Kenneth Rosenzweig  11 , Claudia Henschke  12 , Jeffrey A Kern  13
Affiliations
Free article

Longitudinal quality of life after sublobar resection and stereotactic body radiation therapy for early-stage non-small cell lung cancer

Juan P Wisnivesky et al. Cancer. .
Free article

Abstract

Background: Many patients with early-stage lung cancer are not candidates for lobectomy because of various factors, with treatment options including sublobar resection or stereotactic body radiation therapy (SBRT). Limited information exists regarding patient-centered outcomes after these treatments.

Methods: Subjects with stage I-IIA non-small cell lung cancer (NSCLC) at high risk for lobectomy who underwent treatment with sublobar resection or SBRT were recruited from five medical centers. Quality of life (QOL) was compared with the Short Form 8 (SF-8) for physical and mental health and Functional Assessment of Cancer Therapy-Lung (FACT-L) surveys at baseline (pretreatment) and 7 days, 30 days, 6 months, and 12 months after treatment. Propensity score methods were used to control for confounders.

Results: Of 337 subjects enrolled before treatment, 63% received SBRT. Among patients undergoing resection, 89% underwent minimally invasive video-assisted thoracic surgery or robot-assisted resection. Adjusted analyses showed that SBRT-treated patients had both higher physical health SF-8 scores (difference in differences [DID], 6.42; p = .0008) and FACT-L scores (DID, 2.47; p = .004) at 7 days posttreatment. Mental health SF-8 scores were not different at 7 days (p = .06). There were no significant differences in QOL at other time points, and all QOL scores returned to baseline by 12 months for both groups.

Conclusions: SBRT is associated with better QOL immediately posttreatment compared with sublobar resection. However, both treatment groups reported similar QOL at later time points, with a return to baseline QOL. These findings suggest that sublobar resection and SBRT have a similar impact on the QOL of patients with early-stage lung cancer deemed ineligible for lobectomy.

Keywords: early‐stage lung cancer; limited resection; non–small cell lung cancer; quality of life; stereotactic body radiation therapy.

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References

REFERENCES

    1. Brunelli A, Kim AW, Berger KI, Addrizzo‐Harris DJ. Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians evidence‐based clinical practice guidelines. Chest. 2013;143(suppl 5):e166S‐e190S. doi:10.1378/chest.12‐2395
    1. Zhang Y, Sun Y, Wang R, Ye T, Zhang Y, Chen H. Meta‐analysis of lobectomy, segmentectomy, and wedge resection for stage I non‐small cell lung cancer. J Surg Oncol. 2015;111(3):334‐340. doi:10.1002/jso.23800
    1. Timmerman R, Paulus R, Galvin J, et al. Stereotactic body radiation therapy for inoperable early stage lung cancer. JAMA. 2010;303(11):1070‐1076. doi:10.1001/jama.2010.261
    1. Fakiris AJ, McGarry RC, Yiannoutsos CT, et al. Stereotactic body radiation therapy for early‐stage non‐small‐cell lung carcinoma: four‐year results of a prospective phase II study. Int J Radiat Oncol Biol Phys. 2009;75(3):677‐682. doi:10.1016/j.ijrobp.2008.11.042
    1. Onishi H, Shirato H, Nagata Y, et al. Stereotactic body radiotherapy (SBRT) for operable stage I non‐small‐cell lung cancer: can SBRT be comparable to surgery? Int J Radiat Oncol Biol Phys. 2011;81(5):1352‐1358. doi:10.1016/j.ijrobp.2009.07.1751

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