Head and Neck Mucosal Melanoma: Where Are We Now?

doi:10.1007/s11912-024-01513-w

Review

. 2024 Apr;26(4):421-425.

doi: 10.1007/s11912-024-01513-w. Epub 2024 Mar 21.

Head and Neck Mucosal Melanoma: Where Are We Now?

Curtis Hanba^{1

2}, Ehab Hanna^{3

4}

Affiliations

¹ Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University and Medical College, Taiwan, Republic of China.
² Department of Otolaryngology-Head and Neck Surgery, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
³ Department of Otolaryngology-Head and Neck Surgery, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA. eyhanna@mdanderson.org.
⁴ The University of Texas MD Anderson Cancer Center, Houston, TX, USA. eyhanna@mdanderson.org.

PMID: 38512416
DOI: 10.1007/s11912-024-01513-w

Review

Head and Neck Mucosal Melanoma: Where Are We Now?

Curtis Hanba et al. Curr Oncol Rep. 2024 Apr.

. 2024 Apr;26(4):421-425.

doi: 10.1007/s11912-024-01513-w. Epub 2024 Mar 21.

Authors

Curtis Hanba^{1

2}, Ehab Hanna^{3

4}

Affiliations

¹ Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University and Medical College, Taiwan, Republic of China.
² Department of Otolaryngology-Head and Neck Surgery, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
³ Department of Otolaryngology-Head and Neck Surgery, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA. eyhanna@mdanderson.org.
⁴ The University of Texas MD Anderson Cancer Center, Houston, TX, USA. eyhanna@mdanderson.org.

PMID: 38512416
DOI: 10.1007/s11912-024-01513-w

Abstract

Purpose of review: To highlight recent and relevant treatment considerations while managing mucosal melanoma.

Recent findings: Evidence is building to support the use of targeted therapy and immunotherapy while managing mucosal melanoma. Surgical resection with postoperative radiotherapy plays a major role in managing resectable disease. Recent studies evaluate the addition of targeted, and immunotherapies with an attempt to determine the most efficacious sequence of treatment.

Keywords: Mucosal melanoma; Sinonasal melanoma.

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Treatment and related morbidity of nasal cavity and paranasal sinus cancers.
Smaadahl N, Hool SL, Reinhardt P, Mose L, Hohenberger R, Giger R, Schanne DH, Anschuetz L. Smaadahl N, et al. Front Oncol. 2024 Sep 26;14:1422892. doi: 10.3389/fonc.2024.1422892. eCollection 2024. Front Oncol. 2024. PMID: 39391250 Free PMC article.

References

Bibliography

Papers of particular interest, published recently, have been highlighted as: • Of importance

1. Gal TJ, Silver N, Huang B. Demographics and treatment trends in sinonasal mucosal melanoma. Laryngoscope. 2011;121:2026–33. - DOI
1. Christopherson K, Malyapa RS, Werning JW, Morris CG, Kirwan J, Mendenhall WM. Radiation therapy for mucosal melanoma of the head and neck. Am J Clin Oncol. 2015;38(1):87–9. https://doi.org/10.1097/COC.0b013e31828d73bf . - DOI - PubMed
1. Seetharamu N, Ott PA, Pavlick AC. Mucosal melanomas: a casebased review of the literature. Oncologist. 2010;15:772–81. - DOI - PubMed - PMC
1. Papaspyrou G, Garbe C, Schadendorf D, et al. Mucosal melanomas of the head and neck: new aspects of the clinical outcome, molecular pathology, and treatment with c-kit inhibitors. Melanoma Res. 2011;21:475–82. - DOI - PubMed
1. Edge SB American Joint Committee on Cancer. Ajcc Cancer Staging Manual 8th Ed. 8th ed. New York: Springer; 2017.

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[1] Gal TJ, Silver N, Huang B. Demographics and treatment trends in sinonasal mucosal melanoma. Laryngoscope. 2011;121:2026–33. - DOI

[2] Gal TJ, Silver N, Huang B. Demographics and treatment trends in sinonasal mucosal melanoma. Laryngoscope. 2011;121:2026–33. - DOI

[3] Christopherson K, Malyapa RS, Werning JW, Morris CG, Kirwan J, Mendenhall WM. Radiation therapy for mucosal melanoma of the head and neck. Am J Clin Oncol. 2015;38(1):87–9. https://doi.org/10.1097/COC.0b013e31828d73bf . - DOI - PubMed

[4] Christopherson K, Malyapa RS, Werning JW, Morris CG, Kirwan J, Mendenhall WM. Radiation therapy for mucosal melanoma of the head and neck. Am J Clin Oncol. 2015;38(1):87–9. https://doi.org/10.1097/COC.0b013e31828d73bf . - DOI - PubMed

[5] Seetharamu N, Ott PA, Pavlick AC. Mucosal melanomas: a casebased review of the literature. Oncologist. 2010;15:772–81. - DOI - PubMed - PMC

[6] Seetharamu N, Ott PA, Pavlick AC. Mucosal melanomas: a casebased review of the literature. Oncologist. 2010;15:772–81. - DOI - PubMed - PMC

[7] Papaspyrou G, Garbe C, Schadendorf D, et al. Mucosal melanomas of the head and neck: new aspects of the clinical outcome, molecular pathology, and treatment with c-kit inhibitors. Melanoma Res. 2011;21:475–82. - DOI - PubMed

[8] Papaspyrou G, Garbe C, Schadendorf D, et al. Mucosal melanomas of the head and neck: new aspects of the clinical outcome, molecular pathology, and treatment with c-kit inhibitors. Melanoma Res. 2011;21:475–82. - DOI - PubMed

[9] Edge SB American Joint Committee on Cancer. Ajcc Cancer Staging Manual 8th Ed. 8th ed. New York: Springer; 2017.

[10] Edge SB American Joint Committee on Cancer. Ajcc Cancer Staging Manual 8th Ed. 8th ed. New York: Springer; 2017.

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Head and Neck Mucosal Melanoma: Where Are We Now?

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Head and Neck Mucosal Melanoma: Where Are We Now?

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