doi: 10.1016/j.ajt.2024.03.016.
Epub 2024 Mar 20.
Excess mortality in COVID-19-affected solid organ transplant recipients across the pandemic
Collaborators,
Affiliations
Collaborators
-
Japan Society for Transplantation COVID-19 Registry Study Group:
Kohei Unagami 9 , Hideki Ishida 9 , Kazuya Omoto 10 , Mureo Kasahara 11 , Hajime Uchida 11 , Seisuke Sakamoto 11 , Kenta Futamura 12 , Kenta Nishikawa 13 , Ryoichi Imamura 14 , Shigeaki Nakazawa 14 , Etsuro Hatano 15 , Takashi Ito 15 , Yuki Masano 15 , Morikuni Nishihira 16 , Yuta Hirata 17 , Yasunaru Sakuma 17 , Yasuharu Onishi 17 , Naoki Yokoyama 18 , Shingo Yamamoto 19 , Yusuke Yamada 19 , Yasuhiro Ogura 20 , Nobuhiko Kurata 20 , Junji Uchida 21 , Kazuya Kabei 21 , Hitoshi Iwamoto 22 , Chie Ikeda 22 , Kazunobu Shinoda 23 , Miki Yoshiike 23 , Kiyohiko Hotta 24 , Yuji Hidaka 25 , Daiki Iwami 26 , Yasuo Ishii 27 , Manabu Kamiyama 27 , Tomoharu Yoshizumi 28 , Yukiko Kosai-Fujimoto 28 , Takaaki Kobayashi 29 , Kentaro Motoyama 30 , Megumi Yamamoto 30 , Toshihiro Asai 31 , Masayuki Tasaki 32 , Takashi Kenmochi 33 , Taihei Ito 33 , Kazuaki Tokodai 34 , Atsushi Fujio 34 , Yasumasa Tsukamoto 35 , Takuya Watanabe 35 , Nobuhisa Akamatsu 36 , Sachi Yamashina 37 , Daisuke Ishii 38 , Kazuki Kitajima 38 , Yasutoshi Yamada 39 , Akihiko Mitsuke 39 , Takashi Sakaguchi 39 , Michio Nakamura 40 , Yusuke Tomita 40 , Yuki Nakamura 41 , Tatsuro Ishimoto 42 , Hideki Ohdan 43 , Naoki Tanimine 43 , Takuzo Fujiwara 44 , Mitsuki Yanagihara 44 , Shingo Hatakeyama 45 , Manabu Takai 46 , Kazuhiro Nose 47 , Takashi Kikuchi 47 , Yasunori Mori 47 , Motoo Araki 48 , Takanori Sekito 48 , Shingo Nishimura 48 , Tatsu Tanabe 27 , Yuto Igarashi 49 , Sumi Hidaka 49 , Masaaki Watanabe 50 , Yuichi Ariyoshi 51 , Yasushi Hasegawa 52 , Masato Kamiyama 52 , Tatsuo Yoneda 53 , Tomokazu Shimizu 54 , Kouhei Nishikawa 55 , Takumi Fukumoto 56 , Kaoru Kuramitsu 56 , Masashi Kato 57 , Mitsuru Saito 58 , Makoto Shinkai 59 , Hidehito Usui 59 , Masaaki Sato 60 , Hidetoshi Eguchi 61 , Hiroki Imamura 61 , Shogo Kobayashi 61 , Yuji Soejima 62 , Atsuyoshi Mita 62 , Takashi Kobayashi 63 , Kenji Nakamura 63 , Masayuki Ohtsuka 64 , Shinichiro Nakada 64 , Takahito Yagi 65 , Kazuya Yasui 65 , Naoto Matsuno 66 , Chiharu Mizuno 66 , Mikio Sugimoto 67 , Nobufumi Ueda 67 , Yoshinori Okada 68 , Takashi Hirama 68 , Shinichi Toyooka 69 , Seiichiro Sugimoto 69 , Kei Matsubara 69 , Toru Ikegami 70 , Kenei Furukawa 70 , Hiroyuki Nitta 71 , Hirokatsu Katagiri 71 , Toru Onita 72 , Takeshi Shiraishi 73 , Shugo Mizuno 74 , Eisuke Amiya 75 , Yasushi Shintani 76 , Takashi Kanou 76 , Soichiro Funaki 76 , Yoshifumi Miura 77 , Daisuke Nakajima 78 , Taizen Urahashi 79 , Goro Matsumiya 80 , Michiko Watanabe 80 , Yosuke Ebisu 81 , Ryosuke Osawa 81 , Minoru Ono 82 , Hiroshi Sogawa 83 , Harumi Gomi 84 , Toyofumi Chen-Yoshikawa 85 , Kazunari Yoshida 86 , Naoko Ogawa 87
Affiliations
- 1 Department of Surgery, Japanese Red Cross Kumamoto Hospital, Nagamine-Minami, Higashi Ward, Kumamoto, Japan.
- 2 Department of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences, Honjō, Chuo Ward, Kumamoto, Japan.
- 3 Department of Public Health, Osaka Metropolitan University Graduate School of Medicine, Asahimachi, Abeno Ward, Osaka, Japan.
- 4 Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kajiichō, Kamigyo Ward, Kyoto, Japan.
- 5 Solid Organ Transplant Infectious Diseases, Miami Transplant Institute, Jackson Health System, Miami, Florida, USA; Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
- 6 Department of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences, Honjō, Chuo Ward, Kumamoto, Japan. Electronic address: taizohibi@gmail.com.
- 7 Department of Transplantation Surgery, National Hospital Organization Mito Medical Center, Sakuranosato, Ibaraki, Higashiibaraki District, Ibaraki, Japan.
- 8 Department of Surgery, Tokyo Women's Medical University, Kawadacho, Shinjuku Ward, Tokyo, Japan.
- 9 Department of Organ Transplant Medicine, Tokyo Women's Medical University, Tokyo, Japan.
- 10 Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
- 11 Organ Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
- 12 Department of Transplant Nephrology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan.
- 13 Department of Nephrology, Toho University Faculty of Medicine, Tokyo, Japan.
- 14 Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan.
- 15 Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
- 16 Department of Nephrology, Yuuai medical center, Tomishiro, Okinawa, Japan.
- 17 Division of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
- 18 Division of Urology, Department of Surgery, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
- 19 Department of Urology, Hyogo College of Medicine, Hyogo, Japan.
- 20 Department of Transplantation Surgery, Nagoya University Hospital, Aichi, Japan.
- 21 Department of Urology, Graduate School of Medicine, Osaka Metropolitan University, Asahi-Machi, Abeno-ku, Osaka, Japan.
- 22 Department of Kidney Transplantation Surgery, Hachioji Medical Center, Tokyo Medical University, Hachioji-shi, Tokyo, Japan.
- 23 Department of Urology, St. Marianna University School of Medicine, Kawasaki, Japan.
- 24 Department of Urology, Hokkaido University Hospital, Sapporo, Japan.
- 25 Department of Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.
- 26 Department of Renal Surgery and Transplantation, Jichi Medical University Hospital, Shimotsuke, Japan.
- 27 Department of Surgery, Toranomon Hospital Kidney Center, Tokyo, Japan.
- 28 Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
- 29 Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Aichi, Japan.
- 30 Department of Surgery, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan.
- 31 Department of Renal Transplant and Dialysis, Osaka City General Hospital, Osaka, Japan.
- 32 Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
- 33 Department of Transplantation and Regenerative Medicine, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan.
- 34 Department of Surgery, Tohoku University, Sendai, Japan.
- 35 Department of Transplant Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
- 36 Hepato-Biliary and Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
- 37 Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
- 38 Department of Urology, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan.
- 39 Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
- 40 Department of Transplant Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
- 41 Department of Gastroenterological, Breast and Transplant Surgery, Hiroshima Prefectural Hospital, 1-5-54, Ujina-Kanda, Minami-ku, Hiroshima, 734-8530, Japan.
- 42 Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University. Hiroshima, Japan.
- 43 Department of Surgery, National Hospital Organization, Okayama Medical Center, Okayama, Japan.
- 44 Department of Advanced Blood Purification Therapy, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.
- 45 Department of Urology, Graduate School of Medicine, Gifu University, Gifu, Japan.
- 46 Department of Urology, Kindai University Faculty of Medicine, Osaka, Japan.
- 47 Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
- 48 Department of Kidney Transplant Surgery, Sapporo City General Hospital, Hokkaido, Japan.
- 49 Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kanagawa, Japan.
- 50 Department of Transplant Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
- 51 Department of Renal Surgery, Hidaka Hospital, Gunma, Japan.
- 52 Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
- 53 Department of Urology, Nara Medical University, Kashihara, Nara, Japan.
- 54 Department of Urology and Transplant Surgery, Toda Chuo General Hospital, Saitama, Japan.
- 55 Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Mie, Japan.
- 56 Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
- 57 Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
- 58 Division of Blood Purification, Akita University Hospital, Akita, Japan.
- 59 Department of Surgery, Kanagawa Children's Medical Center, Yokohama, Japan.
- 60 Department of Thoracic Surgery, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
- 61 Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
- 62 Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
- 63 Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
- 64 Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
- 65 Department of Gastroenterological Surgery, Okayama University Hospital, Okayama, Japan.
- 66 Department of Transplantation Technology and Therapeutic Development, Asahikawa Medical University, Hokkaido, Japan.
- 67 Department of Urology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
- 68 Department of Thoracic Surgery, Tohoku University Hospital, Sendai, Miyagi, Japan.
- 69 Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Okayama University, Okayama, Japan.
- 70 Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
- 71 Department of Surgery, Iwate Medical University School of Medicine, Morioka, Japan.
- 72 Department of Urology, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan.
- 73 Department of General Thoracic, Breast and Pediatric Surgery, Fukuoka University School of Medicine, Fukuoka, Japan.
- 74 Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University, Tsu, Mie, Japan.
- 75 Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
- 76 Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
- 77 Department of Surgery, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
- 78 Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
- 79 Departments of Surgery, Dokkyo Medical University, Saitama, Japan.
- 80 Department of Cardiovascular Surgery, Chiba University Graduate School of Medicine, Chiba, Chiba, Japan.
- 81 Department of Infectious Disease, Kameda Medical Center, Chiba, Japan.
- 82 Department of Cardiac Surgery, Tokyo University, Tokyo, Japan.
- 83 Department of Surgery, Westchester Medical Center/New York Medical College, New York, USA.
- 84 Department of Public Health, International University of Health and Welfare, Chiba, Japan.
- 85 Department of Thoracic Surgery, Nagoya University, Aichi, Japan.
- 86 Ebisu Garden Clinic Dialysis Center / Kitasato Univ. Urology.
- 87 Department of Transplantation Surgery, National Hospital Organization Mito Medical Center, Mito, Japan.
- PMID: 38514016
- DOI: 10.1016/j.ajt.2024.03.016
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Excess mortality in COVID-19-affected solid organ transplant recipients across the pandemic
Shigeyoshi Yamanaga et al.
Am J Transplant.
2024 Aug.
Free article
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doi: 10.1016/j.ajt.2024.03.016.
Epub 2024 Mar 20.
Authors
Collaborators
-
Japan Society for Transplantation COVID-19 Registry Study Group:
Kohei Unagami 9 , Hideki Ishida 9 , Kazuya Omoto 10 , Mureo Kasahara 11 , Hajime Uchida 11 , Seisuke Sakamoto 11 , Kenta Futamura 12 , Kenta Nishikawa 13 , Ryoichi Imamura 14 , Shigeaki Nakazawa 14 , Etsuro Hatano 15 , Takashi Ito 15 , Yuki Masano 15 , Morikuni Nishihira 16 , Yuta Hirata 17 , Yasunaru Sakuma 17 , Yasuharu Onishi 17 , Naoki Yokoyama 18 , Shingo Yamamoto 19 , Yusuke Yamada 19 , Yasuhiro Ogura 20 , Nobuhiko Kurata 20 , Junji Uchida 21 , Kazuya Kabei 21 , Hitoshi Iwamoto 22 , Chie Ikeda 22 , Kazunobu Shinoda 23 , Miki Yoshiike 23 , Kiyohiko Hotta 24 , Yuji Hidaka 25 , Daiki Iwami 26 , Yasuo Ishii 27 , Manabu Kamiyama 27 , Tomoharu Yoshizumi 28 , Yukiko Kosai-Fujimoto 28 , Takaaki Kobayashi 29 , Kentaro Motoyama 30 , Megumi Yamamoto 30 , Toshihiro Asai 31 , Masayuki Tasaki 32 , Takashi Kenmochi 33 , Taihei Ito 33 , Kazuaki Tokodai 34 , Atsushi Fujio 34 , Yasumasa Tsukamoto 35 , Takuya Watanabe 35 , Nobuhisa Akamatsu 36 , Sachi Yamashina 37 , Daisuke Ishii 38 , Kazuki Kitajima 38 , Yasutoshi Yamada 39 , Akihiko Mitsuke 39 , Takashi Sakaguchi 39 , Michio Nakamura 40 , Yusuke Tomita 40 , Yuki Nakamura 41 , Tatsuro Ishimoto 42 , Hideki Ohdan 43 , Naoki Tanimine 43 , Takuzo Fujiwara 44 , Mitsuki Yanagihara 44 , Shingo Hatakeyama 45 , Manabu Takai 46 , Kazuhiro Nose 47 , Takashi Kikuchi 47 , Yasunori Mori 47 , Motoo Araki 48 , Takanori Sekito 48 , Shingo Nishimura 48 , Tatsu Tanabe 27 , Yuto Igarashi 49 , Sumi Hidaka 49 , Masaaki Watanabe 50 , Yuichi Ariyoshi 51 , Yasushi Hasegawa 52 , Masato Kamiyama 52 , Tatsuo Yoneda 53 , Tomokazu Shimizu 54 , Kouhei Nishikawa 55 , Takumi Fukumoto 56 , Kaoru Kuramitsu 56 , Masashi Kato 57 , Mitsuru Saito 58 , Makoto Shinkai 59 , Hidehito Usui 59 , Masaaki Sato 60 , Hidetoshi Eguchi 61 , Hiroki Imamura 61 , Shogo Kobayashi 61 , Yuji Soejima 62 , Atsuyoshi Mita 62 , Takashi Kobayashi 63 , Kenji Nakamura 63 , Masayuki Ohtsuka 64 , Shinichiro Nakada 64 , Takahito Yagi 65 , Kazuya Yasui 65 , Naoto Matsuno 66 , Chiharu Mizuno 66 , Mikio Sugimoto 67 , Nobufumi Ueda 67 , Yoshinori Okada 68 , Takashi Hirama 68 , Shinichi Toyooka 69 , Seiichiro Sugimoto 69 , Kei Matsubara 69 , Toru Ikegami 70 , Kenei Furukawa 70 , Hiroyuki Nitta 71 , Hirokatsu Katagiri 71 , Toru Onita 72 , Takeshi Shiraishi 73 , Shugo Mizuno 74 , Eisuke Amiya 75 , Yasushi Shintani 76 , Takashi Kanou 76 , Soichiro Funaki 76 , Yoshifumi Miura 77 , Daisuke Nakajima 78 , Taizen Urahashi 79 , Goro Matsumiya 80 , Michiko Watanabe 80 , Yosuke Ebisu 81 , Ryosuke Osawa 81 , Minoru Ono 82 , Hiroshi Sogawa 83 , Harumi Gomi 84 , Toyofumi Chen-Yoshikawa 85 , Kazunari Yoshida 86 , Naoko Ogawa 87
Affiliations
- 1 Department of Surgery, Japanese Red Cross Kumamoto Hospital, Nagamine-Minami, Higashi Ward, Kumamoto, Japan.
- 2 Department of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences, Honjō, Chuo Ward, Kumamoto, Japan.
- 3 Department of Public Health, Osaka Metropolitan University Graduate School of Medicine, Asahimachi, Abeno Ward, Osaka, Japan.
- 4 Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kajiichō, Kamigyo Ward, Kyoto, Japan.
- 5 Solid Organ Transplant Infectious Diseases, Miami Transplant Institute, Jackson Health System, Miami, Florida, USA; Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
- 6 Department of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences, Honjō, Chuo Ward, Kumamoto, Japan. Electronic address: taizohibi@gmail.com.
- 7 Department of Transplantation Surgery, National Hospital Organization Mito Medical Center, Sakuranosato, Ibaraki, Higashiibaraki District, Ibaraki, Japan.
- 8 Department of Surgery, Tokyo Women's Medical University, Kawadacho, Shinjuku Ward, Tokyo, Japan.
- 9 Department of Organ Transplant Medicine, Tokyo Women's Medical University, Tokyo, Japan.
- 10 Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
- 11 Organ Transplantation Center, National Center for Child Health and Development, Tokyo, Japan.
- 12 Department of Transplant Nephrology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan.
- 13 Department of Nephrology, Toho University Faculty of Medicine, Tokyo, Japan.
- 14 Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan.
- 15 Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
- 16 Department of Nephrology, Yuuai medical center, Tomishiro, Okinawa, Japan.
- 17 Division of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
- 18 Division of Urology, Department of Surgery, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
- 19 Department of Urology, Hyogo College of Medicine, Hyogo, Japan.
- 20 Department of Transplantation Surgery, Nagoya University Hospital, Aichi, Japan.
- 21 Department of Urology, Graduate School of Medicine, Osaka Metropolitan University, Asahi-Machi, Abeno-ku, Osaka, Japan.
- 22 Department of Kidney Transplantation Surgery, Hachioji Medical Center, Tokyo Medical University, Hachioji-shi, Tokyo, Japan.
- 23 Department of Urology, St. Marianna University School of Medicine, Kawasaki, Japan.
- 24 Department of Urology, Hokkaido University Hospital, Sapporo, Japan.
- 25 Department of Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.
- 26 Department of Renal Surgery and Transplantation, Jichi Medical University Hospital, Shimotsuke, Japan.
- 27 Department of Surgery, Toranomon Hospital Kidney Center, Tokyo, Japan.
- 28 Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
- 29 Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Aichi, Japan.
- 30 Department of Surgery, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan.
- 31 Department of Renal Transplant and Dialysis, Osaka City General Hospital, Osaka, Japan.
- 32 Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
- 33 Department of Transplantation and Regenerative Medicine, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan.
- 34 Department of Surgery, Tohoku University, Sendai, Japan.
- 35 Department of Transplant Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
- 36 Hepato-Biliary and Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
- 37 Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
- 38 Department of Urology, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan.
- 39 Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
- 40 Department of Transplant Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
- 41 Department of Gastroenterological, Breast and Transplant Surgery, Hiroshima Prefectural Hospital, 1-5-54, Ujina-Kanda, Minami-ku, Hiroshima, 734-8530, Japan.
- 42 Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University. Hiroshima, Japan.
- 43 Department of Surgery, National Hospital Organization, Okayama Medical Center, Okayama, Japan.
- 44 Department of Advanced Blood Purification Therapy, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.
- 45 Department of Urology, Graduate School of Medicine, Gifu University, Gifu, Japan.
- 46 Department of Urology, Kindai University Faculty of Medicine, Osaka, Japan.
- 47 Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
- 48 Department of Kidney Transplant Surgery, Sapporo City General Hospital, Hokkaido, Japan.
- 49 Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kanagawa, Japan.
- 50 Department of Transplant Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
- 51 Department of Renal Surgery, Hidaka Hospital, Gunma, Japan.
- 52 Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
- 53 Department of Urology, Nara Medical University, Kashihara, Nara, Japan.
- 54 Department of Urology and Transplant Surgery, Toda Chuo General Hospital, Saitama, Japan.
- 55 Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Mie, Japan.
- 56 Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
- 57 Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
- 58 Division of Blood Purification, Akita University Hospital, Akita, Japan.
- 59 Department of Surgery, Kanagawa Children's Medical Center, Yokohama, Japan.
- 60 Department of Thoracic Surgery, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
- 61 Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
- 62 Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
- 63 Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
- 64 Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
- 65 Department of Gastroenterological Surgery, Okayama University Hospital, Okayama, Japan.
- 66 Department of Transplantation Technology and Therapeutic Development, Asahikawa Medical University, Hokkaido, Japan.
- 67 Department of Urology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
- 68 Department of Thoracic Surgery, Tohoku University Hospital, Sendai, Miyagi, Japan.
- 69 Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Okayama University, Okayama, Japan.
- 70 Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
- 71 Department of Surgery, Iwate Medical University School of Medicine, Morioka, Japan.
- 72 Department of Urology, National Hospital Organization Nagasaki Medical Center, Omura, Nagasaki, Japan.
- 73 Department of General Thoracic, Breast and Pediatric Surgery, Fukuoka University School of Medicine, Fukuoka, Japan.
- 74 Department of Hepatobiliary Pancreatic and Transplant Surgery, Mie University, Tsu, Mie, Japan.
- 75 Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
- 76 Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
- 77 Department of Surgery, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
- 78 Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
- 79 Departments of Surgery, Dokkyo Medical University, Saitama, Japan.
- 80 Department of Cardiovascular Surgery, Chiba University Graduate School of Medicine, Chiba, Chiba, Japan.
- 81 Department of Infectious Disease, Kameda Medical Center, Chiba, Japan.
- 82 Department of Cardiac Surgery, Tokyo University, Tokyo, Japan.
- 83 Department of Surgery, Westchester Medical Center/New York Medical College, New York, USA.
- 84 Department of Public Health, International University of Health and Welfare, Chiba, Japan.
- 85 Department of Thoracic Surgery, Nagoya University, Aichi, Japan.
- 86 Ebisu Garden Clinic Dialysis Center / Kitasato Univ. Urology.
- 87 Department of Transplantation Surgery, National Hospital Organization Mito Medical Center, Mito, Japan.
- PMID: 38514016
- DOI: 10.1016/j.ajt.2024.03.016
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Abstract
The excess mortality of coronavirus disease 2019 (COVID-19) solid organ transplant recipients (SOTRs) throughout the pandemic remains unclear. This prospective cohort study based on the Japanese nationwide registry included 1632 SOTRs diagnosed with COVID-19 between February 1, 2020, and July 31, 2022, categorized based on dominant phases of variants of concern (VOCs): Waves 1 to 3 (Beta), 4 (Alpha), 5 (Delta), 6 (Omicron BA.1/BA.2), and 7 (Omicron BA.5). Excess mortality of COVID-19-affected SOTRs was analyzed by calculating standardized mortality ratios (SMRs). Overall, 1632 COVID-19-confirmed SOTRs included 1170 kidney, 408 liver, 25 lung, 20 heart, 1 small intestine, and 8 multiorgan recipients. Although disease severity and all-cause mortality decreased as VOCs transitioned, SMRs of SOTRs were consistently higher than those of the general population throughout the pandemic, showing a U-shaped gap that peaked toward the Omicron BA.5 phase; SMR (95% CI): 6.2 (3.1-12.5), 4.0 (1.5-10.6), 3.0 (1.3-6.7), 8.8 (5.3-14.5), and 21.9 (5.5-87.6) for Waves 1 to 3 (Beta), Wave 4 (Alpha), Wave 5 (Delta), Wave 6 (Omicron BA.1/2), and Wave 7 (Omicron BA.5), respectively. In conclusion, COVID-19 SOTRs had greater SMRs than the general population across the pandemic. Vaccine boosters, immunosuppression optimization, and other protective measures, particularly for older SOTRs, are paramount.
Keywords: COVID-19; excess mortality; organ transplantation; standardized mortality ratio.
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of competing interest The authors of this manuscript have no conflicts of interest to disclose as described by the American Journal of Transplantation.
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