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Review
. 2024 Jun;44(6):920-923.
doi: 10.1038/s41372-024-01941-3. Epub 2024 Mar 21.

Is it time for a precision health approach to the management of newborn hyperbilirubinemia?

David K Stevenson  1 , Grant S Wells  2 , Ronald J Wong  3
Affiliations
Review

Is it time for a precision health approach to the management of newborn hyperbilirubinemia?

David K Stevenson et al. J Perinatol. 2024 Jun.

Abstract

Newborn hyperbilirubinemia during the first two weeks of life is one of most common problems requiring management decisions by a pediatrician. However, high bilirubin levels in the circulation have been associated with neurologic injury under a variety of conditions encountered in the newborn infant, such as hemolysis. The risk for developing dangerous hyperbilirubinemia is multifactorial and is determined by a complex set of factors related to a newborn infant's genetic capacities as well as intra- and extrauterine exposures. To this end, a precision health approach based on the integration of prenatal genetic and postnatal diagnostic measures might improve the management of neonatal hyperbilirubinemia.

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References

    1. Dennery PA, Seidman DS, Stevenson DK. Neonatal hyperbilirubinemia. N Engl J Med. 2001;344:581–90. - PubMed - DOI
    1. Kemper AR, Newman TB, Slaughter JL, Maisels MJ, Watchko JF, Downs SM, et al. Clinical Practice Guideline Revision: management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2022;150:e2022058859. - PubMed - DOI
    1. Hansen TWR, Wong RJ, Stevenson DK. Molecular physiology and pathophysiology of bilirubin handling by the blood, liver, intestine, and brain in the newborn. Physiol Rev. 2020;100:1291–346. - PubMed - DOI
    1. Tenhunen R, Marver HS, Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA. 1968;61:748–55. - PubMed - PMC - DOI
    1. Wong RJ, Bhutani VK, Stevenson DK. The importance of hemolysis and Its clinical detection in neonates with hyperbilirubinemia. Curr Pediatr Rev. 2017;13:193–8. - PubMed - DOI

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