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. 2023 Jan 20:2:100104.
doi: 10.1016/j.dialog.2023.100104. eCollection 2023 Dec.

Perinatal characteristics and longer-term outcomes in Brazilian children with confirmed or suspected congenital Zika infection: ZIKAction Paediatric Registry

Isadora Cristina de Siqueira  1 , Breno Lima de Almeida  1 , Maria Lucia Costa Lage  1 , Leticia Serra  2 , Alessandra Carvalho  3 , Maricélia Maia de Lima  4 , Maria de Fatima Neri Góes  5 , Marília De Santa Inês Neri Crispim  5 , Mirela Monteiro da Costa Pereira  1 , Bernardo Gratival Gouvea Costa  1 , Heather Bailey  6 , Thomas Byrne  7 , Carlo Giaquinto  8 , Georgina Fernandes  7 , Elisa Ruiz-Burga  6   7 , Claire Thorne  7
Affiliations

Perinatal characteristics and longer-term outcomes in Brazilian children with confirmed or suspected congenital Zika infection: ZIKAction Paediatric Registry

Isadora Cristina de Siqueira et al. Dialogues Health. .

Abstract

Background: Despite growing scientific knowledge of Zika virus (ZIKV) infection, questions remain regarding ZIKV infection in pregnancy and congenital ZIKV syndrome (CZS).

Methods: The ZIKAction Paediatric Registry is an international registry of children with documented ZIKV exposure in utero and/or with confirmed or suspected CZS. Its aim is to characterize these children (i.e., clinical, radiological, neurodevelopmental features) and describe outcomes, longer-term sequelae and management through retrospective case note review. This analysis described the maternal and perinatal characteristics of children in the Registry's Bahia arm, assessed their neuroimaging, ophthalmic, hearing and electroencephalography abnormalities by microcephaly classification and reported on hospitalisations. Children born in 2015-2018 and enrolled 2020-2021 in three public health facilities in Salvador were included.

Results: Of 129 (57% female) children, 15 (11·6%) had laboratory-confirmed congenital ZIKV infection and 114 (88·4%) suspected CZS. At delivery, 15 (11·6%) were normocephalic, 30 (23·3%) moderately microcephalic, and 84 (65·1%) severely microcephalic. Median birth head circumference z-score was -3·51 [IQR, -4·69,-2·73]. During follow-up, all children had abnormal neuroimaging, 80·3% (94/117) abnormal electroencephalogram, 62·2% (77/120) ophthalmic abnormalities, and 27·4% (34/124) hearing impairment. Microcephaly classification was significantly associated with gestational age, and ophthalmological and electroencephalography abnormalities. Of 125 children with hospitalisation data, 52 (41·6%) had been hospitalised by most recent follow-up, at median age of 15·8 [4·0, 34·4] months; infections were the leading cause.

Conclusion: Congenital ZIKV infection is an emerging disease with a varied and incompletely understood spectrum. Continued long-term follow-up is essential to understand longer-term prognosis and to inform future health and educational needs.

Keywords: Congenital Zika Syndrome; Microcephaly; Neurodevelopment; Zika Virus.

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Conflict of interest statement

Claire Thorne and all authors reports financial support was provided by European Commission Horizon 2020.

Figures

Fig. 1
Fig. 1
Patterns of findings among children who ever had an ophthalmological abnormality, hearing impairment or EEG abnormality* (N=115). *all children had at least one abnormal neuroimaging finding.
See this image and copyright information in PMC

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