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Review
. 2024 Apr;22(4):153-167.
doi: 10.1080/14787210.2024.2334054. Epub 2024 Mar 27.

Challenges, risks, and opportunities of antiretroviral drugs in women of reproductive potential

Alexis C Henderson  1 , Preetam Cholli  1 , Margaret A Lampe  1 , Athena P Kourtis  1
Affiliations
Review

Challenges, risks, and opportunities of antiretroviral drugs in women of reproductive potential

Alexis C Henderson et al. Expert Rev Anti Infect Ther. 2024 Apr.

Abstract

Introduction: The HIV/AIDS epidemic has been one of the greatest challenges in global health, significantly affecting women of reproductive potential. Considerable advances in antiretroviral therapy for women living with HIV have contributed to improvements in quality of life, better reproductive and birth outcomes, and a reduced risk of perinatal transmission.

Areas covered: Despite the progress made, persistent challenges in access and adherence to antiretroviral drugs may limit their benefits for some women. More pharmacokinetic and safety studies in pregnant and lactating women are urgently needed, as are prospective surveillance systems to evaluate associations between fetal and infant antiretroviral exposures, drug-drug interactions, and pregnancy outcomes.

Expert opinion: Multipurpose technologies, such as combined HIV and other STI or unintended pregnancy prevention, and innovative delivery methods, such as the development of long-acting antiretrovirals, have the potential to reduce adherence challenges and enhance quality of life for women with HIV. Parallel advances in drug safety testing and surveillance are needed to ensure the health and safety of women with or at risk for HIV and children at risk for perinatal transmission.

Keywords: Antiretroviral; HIV; breastfeeding; infant feeding; pregnancy; reproductive age; women.

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Conflict of interest statement

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

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