Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Sep;54(5):747-752.
doi: 10.1053/j.semnuclmed.2024.02.006. Epub 2024 Mar 21.

FAPI-PET in Cardiovascular Disease

Takahiro Higuchi  1 , Sebastian E Serfling  2 , David M Leistner  3 , Thimoteus Speer  4 , Rudolf A Werner  5
Affiliations
Free article
Review

FAPI-PET in Cardiovascular Disease

Takahiro Higuchi et al. Semin Nucl Med. 2024 Sep.
Free article

Abstract

PET probes targeting fibroblasts are frequently used for varying applications in oncology. In recent years, the clinical spectrum has been expanded towards cardiovascular medicine, e.g., after myocardial infarction, in aortic stenosis or as a non-invasive read-out of atherosclerosis. We herein provide a brief overview of the current status of this PET radiotracer in the context of cardiovascular disease, including translational and clinical evidence. In addition, we will also briefly discuss future applications, e.g., the use of fibroblast-targeting PET to investigate bilateral organ function along the cardiorenal axis.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Rudolf A. Werner reports a relationship with German Research Foundation that includes: funding grants. Rudolf A. Werner reports a relationship with Novartis that includes: consulting or advisory. Rudolf A. Werner reports a relationship with PentixaPharm that includes: consulting or advisory and travel reimbursement. Takahiro Higuchi reports a relationship with German Research Foundation that includes: funding grants. Takahiro Higuchi reports a relationship with Okayama University that includes: funding grants. Takahiro Higuchi reports a relationship with Japan Society for the Promotion of Science that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

LinkOut - more resources