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Published Erratum
. 2024 Mar 22;14(1):6897.
doi: 10.1038/s41598-024-55896-8.

Author Correction: Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress

Hwa-Young Lee #  1 , Seung-Wook Kim #  2 , Geum-Hwa Lee  1 , Min-Kyung Choi  1 , Han-Wool Chung  1 , Yong-Chul Lee  3 , Hyung-Ryong Kim  4 , Ho Jeong Kwon  5 , Han-Jung Chae  6
Affiliations
Published Erratum

Author Correction: Curcumin and Curcuma longa L. extract ameliorate lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress

Hwa-Young Lee et al. Sci Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Curcumin and Curcuma longa L. extract regulate serum levels of AST and ALT and hepatic lipid accumulation in acute and chronic CCl4-models. Rats were intraperitoneally treated with CCl4 (0.1 mL/100 g, body weight) one time for (a) 1 day or (b) every other day for 4 weeks. Curcumin (200 mg/kg) or Curcuma longa L. extract (100, 200, or 300 mg/kg) was given each day for 3 days before CCl4 treatment and once daily after CCl4 treatment. Liver and blood samples were collected from all sacrificed animals. Six-h fasting serum levels of AST and ALT were determined. Six h fasting liver triglyceride, total cholesterol, and LDL-cholesterol levels were measured in the (c) 1 day and (d) 4 week CCl4-treated rats. (e) Representative images of liver sections from each group stained with hematoxylin–eosin and Oil-Red-O for lipid content. Scale bars = 50 µm. The experiments were repeated three times using tissues from at least three different rats. #P < 0.05, ###P < 0.001 vs. the control group; *P < 0.01 vs. the CCl4 group (n = 10 rats per group). Cur: curcumin, CL: Curcuma longa L., AST: aspartate aminotransferase, ALT: alanine aminotransferase.
Figure 2
Figure 2
Curcumin and Curcuma longa L. extract regulate ROS accumulation in acute and chronic CCl4-models. Rats were intraperitoneally treated with CCl4 (0.1 mL/100 g body weight) one time for 1 day or every other day for 4 weeks. Curcumin (200 mg/kg) or Curcuma longa L. extract (100, 200, and 300 mg/kg) was given once daily. (a) Lipid peroxidation activity was measured in 1 day and 4 week CCl4-treated rats. (b) DHE staining in the liver was measured in 1 day and 4 week CCl4-treated rats. (c) Liver tissues from 1 day and 4 week CCl4-treated rats were stained with 4-HNE, and (d) the staining intensity of 4-HNE-positive cells was calculated. (e) Lipid peroxidation activity was measured in the ER fractions from the liver tissues of CCl4-treated rats. The experiments were repeated three times using tissues from at least three different rats. #P < 0.05, ###P < 0.001 vs. the control group; *P < 0.01, **P < 0.05 vs. the CCl4 group (n = 10 rats per group). Cur: curcumin, CL: Curcuma longa L.
See this image and copyright information in PMC

Erratum for

References

    1. Lee HY, Kim SW, Lee GH, et al. Turmeric extract and its active compound, curcumin, protect against chronic CCl4-induced liver damage by enhancing antioxidation. BMC Complement. Altern. Med. 2016;16:316. doi: 10.1186/s12906-016-1307-6. - DOI - PMC - PubMed
    1. Lee GH, Lee HY, Choi MK, et al. Protective effect of Curcuma longa L. extract on CCl4-induced acute hepatic stress. BMC Res. Notes. 2017;10:77. doi: 10.1186/s13104-017-2409-z. - DOI - PMC - PubMed

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