Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar 22;24(1):376.
doi: 10.1186/s12903-024-04086-z.

The association between Dental Fluorosis and COL1A2 gene polymorphism among a Tunisian Population

Rim Kallala  1   2 , Afef Slimani  3   4 , Yosra Gassara  5   6 , Behaeddin Garrach  3 , Sawssen Chouchen  7   8   9 , Hajer Foddha  7   9 , Asma Rouis  10 , Aberraouf Kenani  3   4
Affiliations

The association between Dental Fluorosis and COL1A2 gene polymorphism among a Tunisian Population

Rim Kallala et al. BMC Oral Health. .

Abstract

Dental fluorosis (DF) is a prevalent developmental defect of tooth enamel caused by exposure to excessive fluoride, with the severity dependent on various factors. This study aimed to investigate the association between DF and a specific genetic polymorphism (rs412777) in the COL1A2 gene among a Tunisian population. A case-control study was conducted from July to November 2022, involving a total of 95 participants including 51 cases and 44 controls. Dental examinations and genetic analysis were performed to assess the relationship between the COL1A2 gene polymorphism and DF.The results of allelic distribution revealed that A allele carriers were significantly protected against (DF) when compared to those with the C allele (C vs. A, p = 0.001; OR = 0.375 (0.207-0.672)). This suggests a strong correlation between the presence of the C allele and the risk of developing DF. Additionally, significant association between the CC genotype of rs412777 and an increased risk of DF was found under both codominant and dominant genetic models (P = 0.002 and P < 0.001 respectively).The findings suggest that genetic predisposition plays a relevant role in the development of DF. Further research is needed to explore the potential use of genetic markers for DF and their implications for public health. This study provides the first insights into the genetic factors associated with DF in the Tunisian population, contributing to our understanding of this prevalent dental condition.

Keywords: Esthetic; Fluorides; Fluorine; North Africa; Single nucleotide polymorphism (SNP); Tooth.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

References

    1. Bhagavatula P, Levy SM, Broffitt B, Weber-Gasparoni K, Warren JJ. Timing of fluoride intake and dental fluorosis on late-erupting permanent teeth. Community Dent Oral Epidemiol. 2016;44(1):32–45. doi: 10.1111/cdoe.12187. - DOI - PMC - PubMed
    1. Farid H, Khan FR. Clinical management of severe fluorosis in an adult. BMJ Case Rep. 2012;2012. 10.1136/bcr-2012-007138. - PMC - PubMed
    1. Maatouk F, Jmour B, Ghedira H, Argoubi K, Abid A. DENTAL FLUOROSIS IN KAIROUAN, TUNISIA (in French) Actualités Odonto-Stomatologiques. 1998;315:20.
    1. Mazet P. Les Eaux souterraines riches en fluor dans le monde. USTL: Montpellier. Montpellier (FRA); Montpellier. USTL; IRD; 2002.
    1. González-Casamada C, Nevarez-Rascón M, Nevarez-Rascón A, González-Galván M, Isiordia-Espinoza MA, Bologna-Molina R, et al. Single nucleotide polymorphisms and Dental Fluorosis: a systematic review. Dent J (Basel). 2022;10(11). 10.3390/dj10110211. - PMC - PubMed

LinkOut - more resources