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Review
. 2025 Sep-Oct;33(5):461-465.
doi: 10.1097/CRD.0000000000000689. Epub 2024 Mar 23.

Subcutaneous Furosemide: A Novel to Euvolemia

Ryan Cheikhali  1 , Chloe Kalish  2 , Victoria Maksymiuk  2 , Mohamed Nasereldin  1 , Sameer Bahl  3 , Willi H Frishman  1 , Wilbert S Aronow  3 , Stephen Pan  3
Affiliations
Review

Subcutaneous Furosemide: A Novel to Euvolemia

Ryan Cheikhali et al. Cardiol Rev. 2025 Sep-Oct.

Abstract

Furoscix, a subcutaneous pH-neutral formulation of furosemide, obtained US Food and Drug Administration approval in October 2022 for adult patients with New York Heart Association class II and class III chronic heart failure. This approval marks an anticipated potential shift in the traditional management of decongestive therapy in chronic heart failure patients from the confines of the hospital to more accessible outpatient or home-based care. In this review, we will summarize existing evidence regarding the use of subcutaneous furosemide in comparison to both oral and intravenous formulations, highlighting the demonstrable benefits of its application in both outpatient and inpatient settings, and also discuss several factors that may limit its use.

Keywords: Lasix; furoscix; furosemide; heart failure; subcutaneous.

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Conflict of interest statement

Disclosure: The authors declare no conflict of interest.

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