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. 2024 Mar 23;19(1):20.
doi: 10.1007/s11657-024-01379-2.

Bone mineral density T-scores comparison between obese and non-obese individuals included in a Fracture Liaison Service following a recent fragility fracture

Gauthier Marchasson  1 , Cécile Philippoteaux  1 , Isabelle Legroux-Gérot  2 , Béhal Hélène  3 , Bernard Cortet  2 , Julien Paccou  4
Affiliations

Bone mineral density T-scores comparison between obese and non-obese individuals included in a Fracture Liaison Service following a recent fragility fracture

Gauthier Marchasson et al. Arch Osteoporos. .

Abstract

We used data from a Fracture Liaison Service to compare the mean T-scores of obese and non-obese patients after a recent fragility fracture. After adjusting for age, sex, and diabetes mellitus, T-score values were significantly higher at all measurement sites in obese patients, with a mean difference of 1 SD.

Purpose: This study aimed to compare the mean T-scores of obese and non-obese patients after recent fragility fractures.

Methods: Over a period of 5 and a half years, from January 2016 to May 2021, patients from a fracture liaison service were identified and their demographic characteristics, osteoporosis risk factors, BMD T-scores, and fracture sites were compared between obese (BMI ≥ 30 kg/m2) and non-obese (19 kg/m2 < BMI < 30 kg/m2) patients.

Results: A total of 712 patients were included (80.1% women; mean age 73.8 ± 11.3 years). Sixteen % had type 2 diabetes mellitus and 80% had a major osteoporotic fracture (MOF). 135 patients were obese and 577 non-obese, with obese patients younger (p < 0.001) and more frequently female (p = 0.03). Obese patients presented with fewer hip fractures (10% vs. 21%, p = 0.003) and more proximal humerus fractures (16% vs. 7%, p < 0.001) than non-obese patients. After adjusting for age, sex, and diabetes mellitus, BMD T-score values were significantly higher at all measurement sites (lumbar spine, total hip, and femoral neck) in obese patients than in non-obese patients for all types of fractures, with a mean difference of 1 standard deviation (p < 0.001 for all comparisons). The same results were observed in the population limited to MOF.

Conclusions: Given the crucial role of BMD T-score in determining the need for anti-osteoporotic medication following fragility fractures, it is reasonable to question the existing T-score thresholds in obese patients.

Keywords: Bone Mineral Density; Fracture; Fracture Liaison Service; Obesity; Osteoporosis.

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References

    1. Blüher M (2019) Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol 15(5):288–298 - DOI - PubMed
    1. Smith KB, Smith MS (2016) Obesity Statistics. Prim Care 43(1):121–135 - DOI - PubMed
    1. Ng M, Fleming T, Robinson M et al (2014) Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384(9945):766–781 - DOI - PubMed - PMC
    1. Khan SS, Ning H, Wilkins JT et al (2018) Association of body mass index with lifetime risk of cardiovascular disease and compression of morbidity. JAMA Cardiol 3(4):280–287 - DOI - PubMed - PMC
    1. Lauby-Secretan B, Scoccianti C, Loomis D et al (2016) International agency for research on cancer handbook working group. Body fatness and cancer. N Engl J Med 375(8):794–798 - DOI - PubMed - PMC

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