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. 2024 Aug;45(8):3775-3784.
doi: 10.1007/s10072-024-07452-5. Epub 2024 Mar 23.

Social cognition in Parkinson's disease and functional movement disorders

Maria Caterina Silveri  1   2 , Maria Rita Lo Monaco  3 , Alice Tondinelli  1 , Martina Petracca  2 , Paola Zinzi  2 , Serena Fragapane  2 , Gino Pozzi  2   4 , Francesco Pagnini  1 , Anna Rita Bentivoglio  2   5 , Sonia Di Tella  1
Affiliations

Social cognition in Parkinson's disease and functional movement disorders

Maria Caterina Silveri et al. Neurol Sci. 2024 Aug.

Abstract

Introduction: Functional movement disorders (FMD) can overlap with Parkinson's disease (PD), and distinguishing between the two clinical conditions can be complex. Framing social cognition (theory of mind) (TOM) disorder, attention deficit, and psychodynamic features of FMD and PD may improve diagnosis.

Methods: Subjects with FMD and PD and healthy controls (HC) were administered tasks assessing TOM abilities and attention. The psychodynamic hypothesis of conversion disorder was explored by a questionnaire assessing dissociative symptoms. A comprehensive battery of neuropsychological tasks was also administered to FMD and PD.

Results: Although both FMD and PD scored lower than HC on all TOM tests, significant correlations between TOM and neuropsychological tasks were found only in PD but not in FMD. Only PD showed a reduction in attentional control. Dissociative symptoms occurred only in FMD.

Discussion: Cognitive-affective disturbances are real in FMD, whereas they are largely dependent on cognitive impairment in PD. Attentional control is preserved in FMD compared to PD, consistent with the hypothesis that overload of voluntary attentional orientation may be at the basis of the onset of functional motor symptoms. On a psychodynamic level, the confirmation of dissociative symptoms in FMD supports the conversion disorder hypothesis.

Conclusion: FMD and PD can be distinguished on an affective and cognitive level. At the same time, however, the objective difficulty often encountered in distinguishing between the two pathologies draws attention to how blurred the boundary between 'organic' and 'functional' can be.

Keywords: Attention; Conversion disorders; Functional movement disorders; Parkinson’s disease; Theory of mind.

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