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. 2025 Feb;63(1):789-816.
doi: 10.1007/s10528-024-10742-4. Epub 2024 Mar 24.

Potential Impact of SOD2 (rs4880; p.Val16Ala) Variant with the Susceptibility for Childhood Bronchial Asthma

Nahla H Anber  1 , Hanaa Elsayed Ahmed Shahin  2   3 , Heba K Badawy  4 , Enas A Oraby  1 , Sameh A Mohammed  5 , Esraa Ibrahim A Shaaban  6 , Zeinab Rizk Attia  7 , Shereen Mohamed  8 , Mona Farag Shabana  9 , Mohamed Adel El-Eshmawy  10 , Riham Elsayed  11 , Afaf M Elsaid  12 , Adel I Alalawy  13 , Rami M Elshazli  14
Affiliations

Potential Impact of SOD2 (rs4880; p.Val16Ala) Variant with the Susceptibility for Childhood Bronchial Asthma

Nahla H Anber et al. Biochem Genet. 2025 Feb.

Abstract

Oxidative stress is a sophisticated situation that orignates from the accumulation of reactive free radicals within cellular compartments. The antioxidant mechanism of the MnSOD enzyme facilitates the removal of these lethal oxygen species from cellular components. The main goal of this pertained work is to study the contribution of the SOD2 (rs4880; p.Val16Ala) variant to the development of bronchial asthma among children. The study's design was carried out based on a total of 254 participants including 127 asthmatic children (91 atopic and 36 non-atopic) along with 127 unrelated healthy controls. Allelic discrimination analysis was executed using the T-ARMS-PCR protocol. This potential variant conferred a significant association with decreased risk of bronchial asthmatic children under allelic (OR = 0.56, P-value = 0.002), recessive (OR = 0.32, P-value = 0.011), and dominant (OR = 0.51, P-value = 0.040) models. Additionally, atopic and non-atopic asthmatic children indicated a protection against bronchial asthma development under allelic, and dominant models (p-value < 0.05). Our findings suggested that the SOD2*rs4880 variant was correlated with decreased risk of childhood bronchial asthma.

Keywords: SOD2*Val16Ala; SOD2*rs4880; Oxidative stress and Bronchial asthma.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests. Competing interest: The authors declare that they have no funding, financial relationships, and potential conflicts of interest regarding this work. Ethical Approval: All procedures accomplished in this study were approved with the ethical guidelines of the research committee and with the 1964 Helsinki declarations and its guidelines. Informed Consent: Informed consent was obtained from the children’s guardians that enrolled in this work.

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