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Meta-Analysis
. 2024 Sep;30(6):3771-3787.
doi: 10.1111/odi.14928. Epub 2024 Mar 24.

Mucoadhesive delivery systems for oral candidiasis treatment: A systematic review and meta-analysis

Carolina Yoshi Campos Sugio  1   2 , Amanda Aparecida Maia Neves Garcia  1 , Klaryssa Akemi de Araujo Kitamoto  1   2 , Joel Ferreira Santiago Júnior  3 , Simone Soares  1 , Vinicius Carvalho Porto  1 , Vanessa Migliorini Urban  4 , Priscileila Colerato Ferrari  5 , Maria Helena Fernandes  2 , Karin Hermana Neppelenbroek  1
Affiliations
Meta-Analysis

Mucoadhesive delivery systems for oral candidiasis treatment: A systematic review and meta-analysis

Carolina Yoshi Campos Sugio et al. Oral Dis. 2024 Sep.

Abstract

Objectives: This systematic review and meta-analysis aimed to evaluate the clinical and mycological effectiveness of mucoadhesives as vehicles for drugs or natural products in the treatment of oral candidiasis.

Materials and methods: The search for articles was carried out in the Medline/PubMed, SCOPUS, EMBASE, Web of Science, Cochrane Library, and SciELO databases before August 2023. We selected the studies, extracted the data, evaluated the study quality, graded the evidence, performed the risk of bias, and carried out meta-analysis.

Results: A total of 389 potentially relevant articles were identified, and 11 studies (1869 participants) met the inclusion criteria of the systematic review. The overall risk of bias was considered low. The most common presentation of mucoadhesives was tablets, with miconazole being the most frequently drug used in the delivery system. Mucoadhesives demonstrated comparable efficacy with topical or systemic antifungal agents, with no significant differences between treatments in terms of clinical (RR = 0.907; 95CI = 0.3-1.297; p = 0.591; I2 = 64.648) or mycological (RR = 0.95; 95CI = 0.667-1.360; p = 0.789; I2 = 73.271) efficacy.

Conclusions: Mucoadhesives may be a suitable alternative to conventional treatments, with the advantage of reducing the frequency of application by up to 5 times and the daily dosage by up to 20 times.

Keywords: Candida albicans; antifungal agents; drug delivery systems; oral candidiasis.

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References

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