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Review
. 2024 Mar 15:2024:2247748.
doi: 10.1155/2024/2247748. eCollection 2024.

Coenzyme Q10: A Key Antioxidant in the Management of Diabetes-Induced Cardiovascular Complications-An Overview of Mechanisms and Clinical Evidence

Affiliations
Review

Coenzyme Q10: A Key Antioxidant in the Management of Diabetes-Induced Cardiovascular Complications-An Overview of Mechanisms and Clinical Evidence

Fatemeh Samimi et al. Int J Endocrinol. .

Abstract

Background: Diabetes mellitus (DM) presents a significant global health challenge with considerable cardiovascular implications. Coenzyme Q10 (CoQ10) has gained recognition for its potential as a natural antioxidant supplement in the management of diabetes and its associated cardiovascular complications.

Aim: This comprehensive review systematically examines the scientific rationale underlying the therapeutic properties of CoQ10 in mitigating the impact of diabetes and its cardiovascular consequences. The analysis encompasses preclinical trials (in vitro and in vivo) and clinical studies evaluating the efficacy and mechanisms of action of CoQ10. Result & Discussion. Findings reveal that CoQ10, through its potent antioxidant and anti-inflammatory attributes, demonstrates significant potential in reducing oxidative stress, ameliorating lipid profiles, and regulating blood pressure, which are crucial aspects in managing diabetes-induced cardiovascular complications. CoQ10, chemically represented as C59H90O4, was administered in capsule form for human studies at doses of 50, 100, 150, 200, and 300 mg per day and at concentrations of 10 and 20 μM in sterile powder for experimental investigations and 10 mg/kg in powder for mouse studies, according to the published research. Clinical trials corroborate these preclinical findings, demonstrating improved glycemic control, lipid profiles, and blood pressure in patients supplemented with CoQ10.

Conclusion: In conclusion, CoQ10 emerges as a promising natural therapeutic intervention for the comprehensive management of diabetes and its associated cardiovascular complications. Its multifaceted impacts on the Nrf2/Keap1/ARE pathway, oxidative stress, and metabolic regulation highlight its potential as an adjunct in the treatment of diabetes and related cardiovascular disorders. However, further extensive clinical investigations are necessary to fully establish its therapeutic potential and assess potential synergistic effects with other compounds.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
The chemical structure of coenzyme Q10 comprises a benzoquinone ring bonded to an isoprenoid side chain that consists of ten connected isoprenyl groups.
Figure 2
Figure 2
The Nrf2/Keap1/ARE pathway has a role in a wide range of tissues.

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References

    1. Huang D.-D., Shi G., Jiang Y., Yao C., Zhu C. A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications. Biomedicine & Pharmacotherapy . 2020;125 doi: 10.1016/j.biopha.2019.109767.109767 - DOI - PubMed
    1. Damtie S., Workineh L., Berhan A., et al. The magnitude of undiagnosed diabetes mellitus, prediabetes, and associated factors among adults living in Debre Tabor town, northcentral Ethiopia: a community-based cross-sectional study. Heliyon . 2023;9(7) doi: 10.1016/j.heliyon.2023.e17729.17729 - DOI - PMC - PubMed
    1. Nawata K., Ii M., Kassai R. Over-and under-provision of diabetes screening: making more efficient use of healthcare resources. Public Policy Review . 2023;19(1):1–36.
    1. Singh R., Rao H. K., Singh T. G. Advanced glycated end products (ages) in diabetes and its complications: an insight. Plant Arch . 2020;20(1):3838–3841.
    1. Su M., Zhao W., Xu S., Weng J. Resveratrol in treating diabetes and its cardiovascular complications: a review of its mechanisms of action. Antioxidants . 2022;11(6):p. 1085. doi: 10.3390/antiox11061085. - DOI - PMC - PubMed

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