Case of Human Orthohantavirus Infection, Michigan, USA, 2021

Abstract

Orthohantaviruses cause hantavirus cardiopulmonary syndrome; most cases occur in the southwest region of the United States. We discuss a clinical case of orthohantavirus infection in a 65-year-old woman in Michigan and the phylogeographic link of partial viral fragments from the patient and rodents captured near the presumed site of infection.

Keywords: Michigan; New York virus; Orthohantavirus; Sin Nombre virus; United States; bunyavirdiae; genetics; infection; reservoir; transmission; viruses; zoonoses.

Figure

Phylogenetic analysis of orthohantavirus sequence fragments from samples taken from a 65-year-old woman in Michigan, USA, and trapped rodents from the likely site of exposure (blue text). Trees displaying the patient small fragment (481 bp) (A), medium fragment (283 bp) (B), and large fragment (377 bp) (C) were aligned against wild-caught rodents near site of exposure and reference sequences. Numbers along branches indicate bootstrap values of 500 replicates. GenBank accession numbers: human patient, OR428177–9; YR-01, brown adipose fat from a Peromyscus leucopus white-footed mouse, OR428180–2; YR-03, kidney tissue from a P. leucopus mouse, OR428183–5; and YR-10, lung tissue from a Tamias striatus Eastern chipmunk, OR428186–8. Scale bars indicate number of substitutions per site.