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Review
. 2024 Mar-Apr;30(2):79-83.
doi: 10.1097/PPO.0000000000000707.

Melanoma-Modern Treatment for Metastatic Melanoma

Maya Dimitrova  1 , Jeffrey Weber
Affiliations
Review

Melanoma-Modern Treatment for Metastatic Melanoma

Maya Dimitrova et al. Cancer J. 2024 Mar-Apr.

Abstract

Traditional chemotherapy has been ineffective in the treatment of metastatic melanoma. Until the use of checkpoint inhibitors, patients had very limited survival. Since the original US Food and Drug Administration approval of ipilimumab over a decade ago, the armamentarium of immunotherapeutic agents has expanded to include programmed cell death protein 1 and lymphocyte activation gene 3 antibodies, requiring a nuanced approach to the selection of frontline treatments, managing patients through recurrence and progression, and determining length of therapy. Herein, we review the existing evidence supporting current standard immunotherapy regimens and discuss the clinical decision-making involved in treating patients with metastatic melanoma with checkpoint inhibitors.

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Conflict of interest statement

Conflicts of Interest and Source of Funding: The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.

References

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