Health aspects of chloroform--a review

Abstract

First prepared in 1831, chloroform was initially employed as an "ideal" anesthetic. Chloroform was later found to cause heart and liver damage and, with the discovery of safer agents, lost importance as a medical anesthetic. Today chloroform is used primarily as a solvent in industry, in the production of antibiotics, as a cleaning agent, and as an ingredient in pharmaceutical and veterinary formulations. A recent report issued by the National Cancer Institute implicates chloroform as a carcinogen in laboratory rodents. These findings, in conjunction with enforcement of the Delaney Clause have generated renewed interest in chemicals such as chloroform which are not only used in a variety of industrial applications, but which are also available to the general public in a number of food and cosmetic products.