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Randomized Controlled Trial
. 2024 Jun;204(6):2319-2323.
doi: 10.1111/bjh.19382. Epub 2024 Mar 25.

Pneumocystis jirovecii pneumonia in paediatric acute lymphoblastic leukaemia: A report from the multi-international clinical trial AIEOP-BFM ALL 2009

Anke Barnbrock  1 , Anja Möricke  2 , Draga Barbaric  3 , Neil Jones  4 , Christa Koenig  5 , Reinhard Moser  6 , Marius Rohde  7 , Christina Salvador  8 , Julia Alten  2 , Sarah Elitzur  9 , Andreas H Groll  10 , Thomas Lehrnbecher  1
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Free article
Randomized Controlled Trial

Pneumocystis jirovecii pneumonia in paediatric acute lymphoblastic leukaemia: A report from the multi-international clinical trial AIEOP-BFM ALL 2009

Anke Barnbrock et al. Br J Haematol. 2024 Jun.
Free article

Abstract

Pneumocystis jirovecii can cause life-threatening pneumonia (PjP), and patients with haematological malignancies are at high risk of this infection. Prophylactic measures have significantly decreased morbidity and mortality, but there is a paucity of contemporary data on the incidence and clinical course of PjP in well-defined and homogenous patient populations, such as children suffering from acute lymphoblastic leukaemia (ALL). In the multi-international trial AIEOP-BFM ALL2009, PjP was diagnosed in six children (incidence 1/1000) and was associated with insufficient prophylaxis in five of them. Although none of the patients died of PjP, the long-term impact of the infection is unclear.

Keywords: Pneumocystis jirovecii; acute lymphoblastic leukaemia; child; prophylaxis; therapy.

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References

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