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Review
. 2024 May;239(5):e31223.
doi: 10.1002/jcp.31223. Epub 2024 Mar 26.

ZIP transporters-regulated Zn2+ homeostasis: A novel determinant of human diseases

Huimei Liu  1 , Lanfang Li  1   2 , Ruirui Lu  2
Affiliations
Review

ZIP transporters-regulated Zn2+ homeostasis: A novel determinant of human diseases

Huimei Liu et al. J Cell Physiol. 2024 May.

Abstract

As an essential trace element for organisms, zinc participates in various physiological processes, such as RNA transcription, DNA replication, cell proliferation, and cell differentiation. The destruction of zinc homeostasis is associated with various diseases. Zinc homeostasis is controlled by the cooperative action of zinc transporter proteins that are responsible for the influx and efflux of zinc. Zinc transporter proteins are mainly categorized into two families: Zrt/Irt-like protein (SLC39A/ZIP) family and zinc transporter (SLC30A/ZNT) family. ZIP transporters contain 14 members, namely ZIP1-14, which can be further divided into four subfamilies. Currently, ZIP transporters-regulated zinc homeostasis is one of the research hotspots. Cumulative evidence suggests that ZIP transporters-regulated zinc homeostasis may cause physiological dysfunction and contribute to the onset and progression of diverse diseases, such as cancers, neurological diseases, and cardiovascular diseases. In this review, we initially discuss the structure and distribution of ZIP transporters. Furthermore, we comprehensively review the latest research progress of ZIP transporters-regulated zinc homeostasis in diseases, providing a new perspective into new therapeutic targets for treating related diseases.

Keywords: ZIP transporters; cancers; cardiovascular diseases; neurological diseases; zinc.

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References

REFERENCES

    1. Agarwal, A., Parekh, N., Panner Selvam, M. K., Henkel, R., Shah, R., Homa, S. T., Ramasamy, R., Ko, E., Tremellen, K., Esteves, S., Majzoub, A., Alvarez, J. G., Gardner, D. K., Jayasena, C. N., Ramsay, J. W., Cho, C. L., Saleh, R., Sakkas, D., Hotaling, J. M., … Harlev, A. (2019). Male oxidative stress infertility (MOSI): Proposed Terminology and clinical practice guidelines for management of idiopathic male infertility. The World Journal of Men's Health, 37(3), 296–312. https://doi.org/10.5534/wjmh.190055
    1. Aguirre‐Portolés, C., Payne, R., Trautz, A., Foskett, J. K., Natale, C. A., Seykora, J. T., & Ridky, T. W. (2021). ZIP9 is a druggable determinant of sex differences in melanoma. Cancer Research, 81(23), 5991–6003. https://doi.org/10.1158/0008-5472.CAN-21-0982
    1. Aibar‐Almazán, A., Voltes‐Martínez, A., Castellote‐Caballero, Y., Afanador‐Restrepo, D. F., Carcelén‐Fraile, M. C., & López‐Ruiz, E. (2022). Current status of the diagnosis and management of osteoporosis. International Journal of Molecular Sciences, 23(16), 9465. https://doi.org/10.3390/ijms23169465
    1. Anwanwan, D., Singh, S. K., Singh, S., Saikam, V., & Singh, R. (2020). Challenges in liver cancer and possible treatment approaches. Biochimica et Biophysica Acta (BBA) ‐ Reviews on Cancer, 1873(1), 188314. https://doi.org/10.1016/j.bbcan.2019.188314
    1. Armstrong, D. K., Alvarez, R. D., Backes, F. J., Bakkum‐Gamez, J. N., Barroilhet, L., Behbakht, K., Berchuck, A., Chen, L., Chitiyo, V. C., Cristea, M., DeRosa, M., Eisenhauer, E. L., Gershenson, D. M., Gray, H. J., Grisham, R., Hakam, A., Jain, A., Karam, A., Konecny, G. E., … Hang, L. (2022). NCCN guidelines® insights: Ovarian cancer, version 3.2022: Featured updates to the NCCN guidelines. Journal of the National Comprehensive Cancer Network, 20(9), 972–980. https://doi.org/10.6004/jnccn.2022.0047

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