Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jul 1;50(7):620-626.
doi: 10.1097/DSS.0000000000004174. Epub 2024 Mar 26.

Cutaneous Angiosarcoma Subtypes: A Quantitative Systematic Review of Demographics, Treatments, and Outcomes Within Published Patient-Level Cases

Zachary Kwapnoski  1 , Dillon Clarey  2 , Jihyun Ma  3 , Cynthia M Schmidt  4 , Ashley Wysong  2
Affiliations

Cutaneous Angiosarcoma Subtypes: A Quantitative Systematic Review of Demographics, Treatments, and Outcomes Within Published Patient-Level Cases

Zachary Kwapnoski et al. Dermatol Surg. .

Abstract

Background: Cutaneous angiosarcoma (cAS) is a highly aggressive malignancy arising from the vascular endothelium. Given its rarity, there is insufficient data detailing patient demographics, management, and survival outcomes.

Objective: To systematically compile published patient-level cases of cAS and to quantify and analyze data on demographics, management, and outcomes while determining prognostic indicators.

Materials and methods: Searches of EBSCOhost, MEDLINE, EMBASE, and the Cochrane Library generated 1,500 cases of cAS with individual level data available. PRISMA guidelines were followed.

Results: Cutaneous angiosarcoma presented most often on the scalp of elderly men. Metastasis occurred in 36.3% of cases. Aggregate 5-year survival was 31.6% with the median survival of 25 months. The best 5-year survival was in the radiation-associated subtype (48.8%), whereas the worst was in the Stewart-Treves subtype (21.6%). Using multivariate analysis, gender, age group, disease subtype, treatment modality, and metastasis at presentation had significant effects on survival outcomes ( p < .05).

Conclusion: The breadth of information obtained enables this study to serve as a resource that clinicians may reference when they encounter cAS.

PubMed Disclaimer

References

    1. Mark RJ, Poen JC, Tran LM, Fu YS, et al. Angiosarcoma. A report of 67 patients and a review of the literature. Cancer 1996;77:2400–6.
    1. Mendenhall WM, Mendenhall CM, Werning JW, Reith JD, et al. Cutaneous angiosarcoma. Am J Clin Oncol 2006;29:524–8.
    1. Morrison WH, Byers RM, Garden AS, Evans HL, et al. Cutaneous angiosarcoma of the head and neck. A therapeutic dilemma. Cancer 1995;76:319–27.
    1. Guadagnolo BA, Zagars GK, Araujo D, Ravi V, et al. Outcomes after definitive treatment for cutaneous angiosarcoma of the face and scalp. Head Neck 2011;33:661–7.
    1. Young RJ, Brown NJ, Reed MW, Hughes D, et al. Angiosarcoma. Lancet Oncol 2010;11:983–91.

Publication types

LinkOut - more resources