Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Devon Conway reports a relationship with Bristol Myers Squibb Co that includes: consulting or advisory and funding grants. Devon Conway reports a relationship with Biogen Inc that includes: funding grants and speaking and lecture fees. Karlo Toljan reports a relationship with National Multiple Sclerosis Society that includes: funding grants. Devon Conway reports a relationship with Novartis Pharmaceuticals Corporation that includes: consulting or advisory and funding grants. Devon Conway reports a relationship with Horizon Therapeutics USA Inc that includes: funding grants. Devon Conway reports a relationship with Alexion that includes: consulting or advisory. Devon Conway reports a relationship with EMD Serono Inc that includes: funding grants. Devon Conway reports a relationship with US Department of Defense that includes: funding grants. Devon Conway reports a relationship with TG Therapeutics Inc that includes: consulting or advisory. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.