Advances and Applications of Cancer Organoids in Drug Screening and Personalized Medicine

doi:10.1007/s12015-024-10714-6

Review

. 2024 Jul;20(5):1213-1226.

doi: 10.1007/s12015-024-10714-6. Epub 2024 Mar 27.

Advances and Applications of Cancer Organoids in Drug Screening and Personalized Medicine

Yujia Yang^{1

2}, Yajie Kong^{1

2}, Jinlei Cui³, Yu Hou^{1

2}, Zhanjing Gu^{1

2}, Cuiqing Ma^{4

5

6}

Affiliations

¹ Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, China.
² Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, China.
³ Immunology Department, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, China.
⁴ Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, China. macuiqing@hebmu.edu.cn.
⁵ Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, China. macuiqing@hebmu.edu.cn.
⁶ Immunology Department, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, China. macuiqing@hebmu.edu.cn.

PMID: 38532032
DOI: 10.1007/s12015-024-10714-6

Review

Advances and Applications of Cancer Organoids in Drug Screening and Personalized Medicine

Yujia Yang et al. Stem Cell Rev Rep. 2024 Jul.

. 2024 Jul;20(5):1213-1226.

doi: 10.1007/s12015-024-10714-6. Epub 2024 Mar 27.

Authors

Yujia Yang^{1

2}, Yajie Kong^{1

2}, Jinlei Cui³, Yu Hou^{1

2}, Zhanjing Gu^{1

2}, Cuiqing Ma^{4

5

6}

Affiliations

¹ Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, China.
² Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, China.
³ Immunology Department, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, China.
⁴ Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, China. macuiqing@hebmu.edu.cn.
⁵ Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, China. macuiqing@hebmu.edu.cn.
⁶ Immunology Department, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, China. macuiqing@hebmu.edu.cn.

PMID: 38532032
DOI: 10.1007/s12015-024-10714-6

Abstract

In recent years, the rapid emergence of 3D organoid technology has garnered significant attention from researchers. These miniature models accurately replicate the structure and function of human tissues and organs, offering more physiologically relevant platforms for cancer research. These intricate 3D structures not only serve as promising models for studying human cancer, but also significantly contribute to the advancement of various potential applications in the field of cancer research. To date, organoids have been efficiently constructed from both normal and malignant tissues originating from patients. Using such bioengineering platforms, simulations of infections and cancer processes, mutations and carcinogenesis can be achieved, and organoid technology is also expected to facilitate drug testing and personalized therapies. In conclusion, regenerative medicine has the potential to enhance organoid technology and current transplantation treatments by utilizing genetically identical healthy organoids as substitutes for irreversibly deteriorating diseased organs. This review explored the evolution of cancer organoids and emphasized the significant role these models play in fundamental research and the advancement of personalized medicine in oncology.

Keywords: 3D culture; Cancer; Drug screening; Organoids; Personalized medicine; Regeneration medicine.

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References

1. Xu, H., Lyu, X., Yi, M., Zhao, W., Song, Y., & Wu, K. (2018). Organoid technology and applications in cancer research. Journal of Hematology & Oncology, 11(1). https://doi.org/10.1186/s13045-018-0662-9 . [online].
1. Clevers, H., & Tuveson, D. A. (2019). Organoid models for cancer research. Annual Review of Cancer Biology, 3(1), 223–234. https://doi.org/10.1146/annurev-cancerbio-030518-055702 - DOI
1. Yang, L., Yang, S., Li, X., Li, B., Li, Y., Zhang, X., Ma, Y., Peng, X., Jin, H., Fan, Q., Wei, S., Liu, J., & Li, H. (2019). Tumor organoids: From inception to future in cancer research. Cancer Letters, 454, 120–133. https://doi.org/10.1016/j.canlet.2019.04.005 - DOI - PubMed
1. Liu, C., Qin, T., Huang, Y., Li, Y., Chen, G., & Sun, C. (2020). Drug screening model meets cancer organoid technology. Translational Oncology, 13(11). https://doi.org/10.1016/j.tranon.2020.100840 . [online].
1. Kretzschmar, K. (2020). Cancer research using organoid technology. Journal of Molecular Medicine. https://doi.org/10.1007/s00109-020-01990-z - DOI - PubMed

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[1] Xu, H., Lyu, X., Yi, M., Zhao, W., Song, Y., & Wu, K. (2018). Organoid technology and applications in cancer research. Journal of Hematology & Oncology, 11(1). https://doi.org/10.1186/s13045-018-0662-9 . [online].

[2] Xu, H., Lyu, X., Yi, M., Zhao, W., Song, Y., & Wu, K. (2018). Organoid technology and applications in cancer research. Journal of Hematology & Oncology, 11(1). https://doi.org/10.1186/s13045-018-0662-9 . [online].

[3] Clevers, H., & Tuveson, D. A. (2019). Organoid models for cancer research. Annual Review of Cancer Biology, 3(1), 223–234. https://doi.org/10.1146/annurev-cancerbio-030518-055702 - DOI

[4] Clevers, H., & Tuveson, D. A. (2019). Organoid models for cancer research. Annual Review of Cancer Biology, 3(1), 223–234. https://doi.org/10.1146/annurev-cancerbio-030518-055702 - DOI

[5] Yang, L., Yang, S., Li, X., Li, B., Li, Y., Zhang, X., Ma, Y., Peng, X., Jin, H., Fan, Q., Wei, S., Liu, J., & Li, H. (2019). Tumor organoids: From inception to future in cancer research. Cancer Letters, 454, 120–133. https://doi.org/10.1016/j.canlet.2019.04.005 - DOI - PubMed

[6] Yang, L., Yang, S., Li, X., Li, B., Li, Y., Zhang, X., Ma, Y., Peng, X., Jin, H., Fan, Q., Wei, S., Liu, J., & Li, H. (2019). Tumor organoids: From inception to future in cancer research. Cancer Letters, 454, 120–133. https://doi.org/10.1016/j.canlet.2019.04.005 - DOI - PubMed

[7] Liu, C., Qin, T., Huang, Y., Li, Y., Chen, G., & Sun, C. (2020). Drug screening model meets cancer organoid technology. Translational Oncology, 13(11). https://doi.org/10.1016/j.tranon.2020.100840 . [online].

[8] Liu, C., Qin, T., Huang, Y., Li, Y., Chen, G., & Sun, C. (2020). Drug screening model meets cancer organoid technology. Translational Oncology, 13(11). https://doi.org/10.1016/j.tranon.2020.100840 . [online].

[9] Kretzschmar, K. (2020). Cancer research using organoid technology. Journal of Molecular Medicine. https://doi.org/10.1007/s00109-020-01990-z - DOI - PubMed

[10] Kretzschmar, K. (2020). Cancer research using organoid technology. Journal of Molecular Medicine. https://doi.org/10.1007/s00109-020-01990-z - DOI - PubMed

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Advances and Applications of Cancer Organoids in Drug Screening and Personalized Medicine

Affiliations

Advances and Applications of Cancer Organoids in Drug Screening and Personalized Medicine

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