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Randomized Controlled Trial
. 2024 Mar 27;39(1):94.
doi: 10.1007/s10103-024-04042-x.

The effect of combined red, blue, and near-infrared light-emitting diode (LED) photobiomodulation therapy on speed of wound healing after superficial ablative fractional resurfacing

John Soliman  1 , Rachel Elsanadi  1 , Feben Messele  1 , Kristen M Kelly  2   3
Affiliations
Randomized Controlled Trial

The effect of combined red, blue, and near-infrared light-emitting diode (LED) photobiomodulation therapy on speed of wound healing after superficial ablative fractional resurfacing

John Soliman et al. Lasers Med Sci. .

Abstract

Objective of the study is to assess the effects of wound healing with a commercially available light emitting diode (LED) photo biomodulation (PBM) device that emits three wavelengths (465, 640 and 880nm) after ablative fractional laser (AFL) treatment to healthy skin on the bilateral inner biceps. We conducted a prospective intraindividual randomized controlled study with 25 volunteers. AFL treatment was performed on healthy skin of the bilateral inner biceps. Subjects applied the LED light device for 30 min to the assigned bicep 3 times a week over 4 weeks, beginning on day 0. Subjects were followed up on days 2, 4, 6, 9, 13, 20 and 27 for treatment with the PBM device, clinical digital photography of the test and control sites, and in-person subject assessment, with follow ups on days 34 and 55 for clinical photography and assessment. Three blinded evaluators were asked to determine which bicep healed faster between day 0 to day 13. Pain, discomfort, and itch were also assessed. The three blinded evaluators chose the treatment arm as the faster healed arm in greater than 50% of the images, although the results were not statistically significant. There was no statistically significant difference between test and control arms in terms of pain, discomfort and itch. In conclusion, PBM therapy has the potential to improve wound healing. In this study, a three wavelength PBM device resulted in some subjects achieving faster healing after AFL but the results were not statistically significant.

Keywords: Ablative fractional laser; LED treatment; Light-emitting diode; Wound healing.

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Conflict of interest statement

Dr. Kristen M Kelly has the following conflicts of interest to declare: Research grant and equipment from Biophotas for this study.

Figures

Fig. 1
Fig. 1
The figure shows the left inner bicep (top set of images) and right inner bicep (bottom set of images) of subject 35 on day 0 immediately after ablative fractional laser (AFL) treatment, day 2, day 4, day 6, and day 13. The right inner bicep was treated with light emitting diode (LED)
Fig. 2
Fig. 2
Left inner bicep (top set of images) and right inner bicep (bottom set of images) of subject 10 on day 0 immediately after ablative fractional laser (AFL) treatment, day 2, day 4, day 6, day 13. The right inner bicep was treated with light emitting diode (LED)
Fig. 3
Fig. 3
Days to resolution of Erythema, Edema, Crusting, followed up to day 55 in both groups; PBM treated arm and control arm
See this image and copyright information in PMC

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