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Editorial
. 2024 Mar 12:14:1340737.
doi: 10.3389/fonc.2024.1340737. eCollection 2024.

Editorial: Management of peritoneal surface malignancies. (cytoreductive surgery, HIPEC, PIPAC, and beyond)

Amine Souadka  1   2   3 , Naoual Bakrin  4   5
Affiliations
Editorial

Editorial: Management of peritoneal surface malignancies. (cytoreductive surgery, HIPEC, PIPAC, and beyond)

Amine Souadka et al. Front Oncol. .
No abstract available

Keywords: HIPEC (heated intraperitoneal chemotherapy); PIPAC; cytoreductive surgery (CRS); molecular status; peritoneal surface malignancies.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Navigating the Uncharted Waters of Peritoneal Surface Malignancy Management – Key Unresolved Questions. This figure delineates the principal uncertainties and ongoing debates in the treatment of peritoneal surface malignancies. It encompasses a spectrum of critical aspects, from patient selection to the intricacies of surgical and chemotherapeutic interventions. Each segment reflects a pivotal area of inquiry: Patient Selection: The enigma of creating robust, universally applicable criteria for patient eligibility for advanced treatments. Complete Cytoreductive Surgery: The challenge in defining and achieving complete cytoreduction, and the quest for predictive accuracy in preoperative evaluations. HIPEC: The pursuit of standardizing Hyperthermic Intraperitoneal Chemotherapy parameters to balance efficacy and safety. PIPAC: The exploration of long-term efficacy and safety profiles for Pressurized Intraperitoneal Aerosol Chemotherapy. Drug Regimen: The conundrum of optimizing chemotherapeutic agents and regimens tailored to individual patient and tumor profiles. CAR T-Cells and Checkpoint Inhibitors: The exploration into identifying predictive markers for responsiveness to CAR T cells and checkpoint inhibitors in the treatment of peritoneal surface malignancies. Molecular Status: The challenge of integrating molecular diagnostics into personalized treatment strategies. Indication of Each Procedure: The ongoing debate over the specific indications and comparative effectiveness of various treatment modalities.
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  • Editorial on the Research Topic Management of peritoneal surface malignancies. (cytoreductive surgery, HIPEC, PIPAC, and beyond)

References

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