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Case Reports
. 2024 Mar 1;14(1):60-63.
doi: 10.37796/2211-8039.1434. eCollection 2024.

VKORC1 polymorphisms and complete resistance to vitamin K antagonists: About two cases

Affiliations
Case Reports

VKORC1 polymorphisms and complete resistance to vitamin K antagonists: About two cases

Ilham Benyamna et al. Biomedicine (Taipei). .

Abstract

Complete resistance to vitamin K antagonists is a rare but serious condition. It can complicate therapeutic management, especially when direct oral anticoagulants cannot be used. Some single mutations in the VKORC1 gene have been identified in patients partially or completely resistant to vitamin K antagonists. We report the cases of two women in their fifties who presented an unexplained peripheral venous thrombosis. The aetiological assessment did not show any abnormalities. Genetic testing showed that both patients had the VKORC1 5417 GG genotype. The VKORC1 3673 genotype was GG in case 1 and GA in case 2. The two patients showed complete resistance to vitamin K antagonists which required a change in treatment with favourable outcomes. Our goal is to offer optimal care guided by a literature review.

Keywords: Mutations; Resistance to vitamin K antagonists; VKORC1.

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Conflict of interest statement

Conflicts of interest: The authors declare that there is no conflict of interest.

References

    1. Schmeits PC, Hermans MH, van Geest-Daalderop JH, Poodt J, Desauvage Naulting PR, Conemans JM. VKORC1 mutations in patients with partial resistance to phenprocoumon. Br J Haematol. 2010;148:955–7. - PubMed
    1. Wilms EB, Touw DJ, Conemans JM, Veldkamp R, Hermans M. A new VKORC1 allelic variant (p.Trp59Arg) in a patient with partial resistance to acenocoumarol and phenprocoumon. J Thromb Haemostasis. 2008;6:1124–6. - PubMed
    1. Peoc’h K, Pruvot S, Gourmel C, Sollier CB, Drouet L. A new VKORC1 mutation leading to an isolated resistance to fluindione. Br J Haematol. 2009;145:841–3. - PubMed
    1. Sinxadi P, Blockman M. Warfarin resistance. Cardiovasc J Afr. 2008;19:215–7. - PubMed
    1. Takahashi H. Warfarin resistance and related pharmacogenetic information. Brain Nerve. 2008;60:1365–71. - PubMed

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