Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2024 Feb 22;46(3):1694-1699.
doi: 10.3390/cimb46030109.

Advanced Molecular Solutions for Cancer Therapy-The Good, the Bad, and the Ugly of the Biomarker Paradigm

Dumitru Andrei Iacobas  1
Affiliations
Editorial

Advanced Molecular Solutions for Cancer Therapy-The Good, the Bad, and the Ugly of the Biomarker Paradigm

Dumitru Andrei Iacobas. Curr Issues Mol Biol. .

Abstract

Identifying the most effective actionable molecules whose "smart" manipulation might selectively kill/slow down/stop the proliferation of cancer cells, with few side effects on the normal cells of the tissue, was for decades the single major objective of countless investigators [...].

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
Potential distributions of the expression levels of a hypothetical gene biomarker within healthy (H) and cancer-stricken (C) persons. Note that the difference between the expression levels in two healthy individuals (H1 and H2) may be larger than that between the average healthy (AVE-H) person and the average cancer-stricken (C) person.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Iacobas D.A. Molecules at Play in Cancer. Curr. Issues Mol. Biol. 2023;45:2182–2185. doi: 10.3390/cimb45030140. - DOI - PMC - PubMed
    1. The Cancer Genome Atlas (TCGA) Research Network. [(accessed on 4 January 2024)]; Available online: https://www.cancer.gov/tcga.
    1. Moço P.D., Farnós O., Sharon D., Kamen A.A. Targeted Delivery of Chimeric Antigen Receptor into T Cells via CRISPR-Mediated Homology-Directed Repair with a Dual-AAV6 Transduction System. Curr. Issues Mol. Biol. 2023;45:7705–7720. doi: 10.3390/cimb45100486. - DOI - PMC - PubMed
    1. Wünsch A.C., Ries E., Heinzelmann S., Frabschka A., Wagner P.C., Rauch T., Koderer C., El-Mesery M., Volland J.M., Kübler A.C., et al. Metabolic Silencing via Methionine-Based Amino Acid Restriction in Head and Neck Cancer. Curr. Issues Mol. Biol. 2023;45:4557–4573. doi: 10.3390/cimb45060289. - DOI - PMC - PubMed
    1. Hwang J., Moon H., Kim H., Kim K.-Y. Identification of a Novel ERK5 (MAPK7) Inhibitor, MHJ-627, and Verification of Its Potent Anticancer Efficacy in Cervical Cancer HeLa Cells. Curr. Issues Mol. Biol. 2023;45:6154–6169. doi: 10.3390/cimb45070388. - DOI - PMC - PubMed

Publication types