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. 2024 Feb 29;22(3):117.
doi: 10.3390/md22030117.

New Phenol Derivatives from the Haima Cold Seep-Derived Fungus Aspergillus subversicolor CYH-17

Yi-Hao Che  1   2 , Wen-Ping Ding  1 , Zhi-Hui Xiao  1   3 , Jia-Min Wu  1   2 , Hao Yin  1 , Fa-Zuo Wang  1   3 , Si Zhang  1
Affiliations

New Phenol Derivatives from the Haima Cold Seep-Derived Fungus Aspergillus subversicolor CYH-17

Yi-Hao Che et al. Mar Drugs. .

Abstract

Seven new phenol derivatives, subversins A-E (1-5), subversic acid A (6) and epi-wortmannine G (7); one new natural product, 4-hydroxy-7-methoxyphthalide (8); and five known compounds (9-13) were isolated from the fungus Aspergillus subversicolor CYH-17 collected from the Haima cold seep. The structures and absolute configurations of these compounds were determined via NMR, MS, optical rotation, electronic circular dichroism (ECD) calculation, X-ray diffraction analysis and comparison with the literature. Compounds 2 and 5 were two pairs of enantiomers. All compounds were tested for their α-glucosidase and acetylcholinesterase (AChE) inhibitory activity, antioxidant activity and antibacterial activity, but no obvious activity was observed among these studied compounds.

Keywords: activity; cold seep; fungi; phenol derivatives.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Structures of compounds 1–13.
Figure 2
Figure 2
The crystal structure for compound 1.
Figure 3
Figure 3
Key 1H-1H COSY, HMBC and NOESY correlations for compounds 1–8.
See this image and copyright information in PMC

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