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Observational Study
. 2024 Jun;113(6):1435-1443.
doi: 10.1111/apa.17215. Epub 2024 Mar 27.

Functional gastrointestinal disorders, quality of life, and behaviour in adolescents with history of infant colic

Judith Zeevenhooven  1   2 , Lucas Zeevenhooven  1 , Angela Biesbroek  1 , Renske Schappin  1 , Arine M Vlieger  3 , Bregje E van Sleuwen  4 , Monique P L'Hoir  5 , Marc A Benninga  2
Affiliations
Observational Study

Functional gastrointestinal disorders, quality of life, and behaviour in adolescents with history of infant colic

Judith Zeevenhooven et al. Acta Paediatr. 2024 Jun.

Abstract

Aim: To assess the prevalence of functional gastrointestinal disorders (FGIDs), health-related quality of life (HRQOL), and behavioural problems in a cohort of adolescents with a history of infant colic (IC), as defined by Wessel's criteria.

Methods: 388 adolescents, aged 15-18 years, who participated in a randomised controlled trial for infants with colic, were invited for our observational follow-up study. Prevalence of FGIDs was assessed with the Rome IV Questionnaire on Paediatric Gastrointestinal Disorders (RIV-QPGD), HRQOL through self-report of the Paediatric Quality of Life Inventory (PedsQL), and behavioural problems through parent-report of the child behaviour checklist (CBCL). Multivariable models were used to compare prevalence rates of FGIDs and HRQOL scores.

Results: 190 (49%) adolescents with a history of IC (cases) and 381 controls were included (median age 17.0 [IQR 16.0-17.0] and 16.0 [15.0-17.0] years, respectively). Cases had a significantly higher risk for postprandial distress syndrome compared to controls (aOR 2.49 (95%CI 1.18-5.25), p = 0.002). After multivariable regression, total, physical and school HRQOL scores were significantly lower in cases compared to controls (p = 0.003, 0.001, and 0.009).

Conclusion: Adolescents with a history of IC demonstrate higher prevalence rates of postprandial distress syndrome compared to controls. However, conclusions should be made with caution due to attrition and information bias.

Keywords: adolescence; functional gastrointestinal disorders; infant colic; long‐term outcomes.

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References

REFERENCES

    1. Benninga MA, Faure C, Hyman PE, St James Roberts I, Schechter NL, Nurko S. Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology. 2016;150:1443‐1455.e2.
    1. Wessel MA, Cobb JC, Jackson EB, Harris GS, Detwiler AC. Paroxysmal fussing in infancy, sometimes called colic. Pediatrics. 1954;14:421‐435.
    1. Steutel NF, Benninga MA, Langendam MW, de Kruijff I, Tabbers MM. Reporting outcome measures in trials of infant colic. J Pediatr Gastroenterol Nutr. 2014;59:341‐346.
    1. Wolke D, Bilgin A, Samara M. Systematic review and meta‐analysis: fussing and crying durations and prevalence of colic in infants. J Pediatr. 2017;185:55‐61.e4.
    1. Zeevenhooven J, Browne PD, L'Hoir MP, de Weerth C, Benninga MA. Infant colic: mechanisms and management. Nat Rev Gastroenterol Hepatol. 2018;15:479‐496.

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