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Review
. 2024 Mar 21;14(6):553.
doi: 10.3390/nano14060553.

Exploring the Application of Graphene Oxide-Based Nanomaterials in the Repair of Osteoporotic Fractures

Hongfa Zhou  1   2   3   4 , Jinyuan Chen  1   2   3   4 , Xuan Zhang  1   2   3   4 , JingJing Chen  4 , Jiayou Chen  4 , Shicheng Jia  4 , Deli Wang  1   2   3 , Hui Zeng  5 , Jian Weng  1   2   3   4 , Fei Yu  1   2   3   4
Affiliations
Review

Exploring the Application of Graphene Oxide-Based Nanomaterials in the Repair of Osteoporotic Fractures

Hongfa Zhou et al. Nanomaterials (Basel). .

Abstract

Osteoporotic fractures are induced by osteoporosis, which may lead to the degradation of bone tissues and microstructures and impair their healing ability. Conventional internal fixation therapies are ineffective in the treatment of osteoporotic fractures. Hence, developing tissue engineering materials is crucial for repairing osteoporotic fractures. It has been demonstrated that nanomaterials, particularly graphene oxide (GO), possess unique advantages in tissue engineering due to their excellent biocompatibility, mechanical properties, and osteoinductive abilities. Based on that, GO-nanocomposites have garnered significant attention and hold promising prospects for bone repair applications. This paper provides a comprehensive insight into the properties of GO, preparation methods for nanocomposites, advantages of these materials, and relevant mechanisms for osteoporotic fracture applications.

Keywords: graphene oxide; nanomaterial; osteoporotic fractures.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Application of GO-based nanomaterials.
Figure 2
Figure 2
Structural formula of GO and its derivative.
Figure 3
Figure 3
The mechanisms of GO-based nanomaterials affecting osteogenesis.
See this image and copyright information in PMC

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